PMID- 10411346
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20190513
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 58
IP  - 7
DP  - 1999 Jul
TI  - Increased brain-derived neurotrophic factor-containing axons in the basal ganglia 
      of patients with multiple system atrophy.
PG  - 765-72
AB  - Brain-derived neurotrophic factor (BDNF) has a neurotrophic effect not only on 
      mesencephalic dopaminergic neurons, but also on striatal neurons. To investigate 
      whether the abnormal expression of BDNF occurs in the basal ganglia of patients 
      with Parkinson disease (PD) and multiple system atrophy (MSA), we compared the 
      BDNF levels in the striatum and globus pallidus of patients with PD or MSA to 
      controls using immunohistochemistry. Furthermore, to quantitatively evaluate the 
      immunohistochemical changes in the striatum, image analysis of the putamen was 
      performed. BDNF-positive nerve fiber bundles and fine granular structures were 
      scattered throughout the striatum and globus pallidus of all samples. Most of 
      these granular structures were observed in glial fibrillary acidic 
      protein-positive astrocytes. In addition, BDNF-positive neurites were abundant in 
      the striatum of all MSA patients, and numerous BDNF-positive varicose fibers were 
      found in the globus pallidus of some MSA cases with particularly severe striatal 
      involvement. These observations suggest that the upregulated expression of BDNF 
      may occur as a protective mechanism in the striatum of MSA patients, and that 
      severe striatal degeneration may cause the aberrant accumulation of BDNF in the 
      striatal projection areas of the globus pallidus of MSA patients.
FAU - Kawamoto, Y
AU  - Kawamoto Y
AD  - Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Akiguchi, I
AU  - Akiguchi I
FAU - Kimura, J
AU  - Kimura J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Axons/*metabolism
MH  - Basal Ganglia/*metabolism
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corpus Striatum/metabolism
MH  - Female
MH  - Globus Pallidus/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Inclusion Bodies/metabolism
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/*metabolism
MH  - Neurites/metabolism
MH  - Neuroglia/metabolism
EDAT- 1999/07/20 00:00
MHDA- 1999/07/20 00:01
CRDT- 1999/07/20 00:00
PHST- 1999/07/20 00:00 [pubmed]
PHST- 1999/07/20 00:01 [medline]
PHST- 1999/07/20 00:00 [entrez]
AID - 10.1097/00005072-199907000-00010 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1999 Jul;58(7):765-72. doi: 
      10.1097/00005072-199907000-00010.