PMID- 10413189
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20220408
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 134
IP  - 1
DP  - 1999 May 3
TI  - Elevated immunoglobulin E (IgE) levels in children with exposure to environmental 
      lead.
PG  - 63-78
AB  - Lead has been reported to be an immunosuppressive agent in animal systems at 
      levels far below those recognized as overtly toxic. Little data exist on lead's 
      effects on the human immune system, especially in young children who are at 
      greatest risk for exposure to this environmental hazard. The effects of 
      environmental lead exposure on the human immune system were examined in a 
      population of young children, age 9 months-6 years, from the urban population of 
      Springfield-Greene County, Missouri. Reported here are data from 279 children 
      with blood lead levels ranging from 1 to 45 microg/dl. White blood cell 
      populations have been enumerated and examined for cell surface expression of 
      activation markers. Serum has been analyzed for IgE, specific titers to Rubella 
      vaccine, sCD25 (the soluble form of the IL2 receptor), sCD27 (the soluble form of 
      the lymphocyte specific member of the tumor necrosis factor receptor family), and 
      IL4 (the cytokine interleukin 4). Variation of these assays with age of the child 
      was considered in statistical analysis of data. A statistically significant 
      relationship of IgE and blood lead level was found in this population; as blood 
      lead (PbB) level increases, IgE level increases. No other statistically 
      significant differences between risk categories or other associations with blood 
      lead level were found. The exact mechanism for this apparent stimulus of 
      IgE-producing B cells remains to be elucidated. The development of allergic 
      symptoms is often preceded by an increase in IgE. These data indicate that 
      ingested lead could play a role in this process by stimulating IgE production.
FAU - Lutz, P M
AU  - Lutz PM
AD  - Biological Sciences Department, University of Missouri-Rolla, 65401-0249, USA.
FAU - Wilson, T J
AU  - Wilson TJ
FAU - Ireland, J
AU  - Ireland J
FAU - Jones, A L
AU  - Jones AL
FAU - Gorman, J S
AU  - Gorman JS
FAU - Gale, N L
AU  - Gale NL
FAU - Johnson, J C
AU  - Johnson JC
FAU - Hewett, J E
AU  - Hewett JE
LA  - eng
GR  - R01 ESO6065/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 207137-56-2 (Interleukin-4)
RN  - 2P299V784P (Lead)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Immune System/drug effects
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Interleukin-4/blood
MH  - Lead/blood
MH  - Lead Poisoning/*immunology
MH  - Male
EDAT- 1999/07/21 00:00
MHDA- 1999/07/21 00:01
CRDT- 1999/07/21 00:00
PHST- 1999/07/21 00:00 [pubmed]
PHST- 1999/07/21 00:01 [medline]
PHST- 1999/07/21 00:00 [entrez]
AID - S0300-483X(99)00036-0 [pii]
AID - 10.1016/s0300-483x(99)00036-0 [doi]
PST - ppublish
SO  - Toxicology. 1999 May 3;134(1):63-78. doi: 10.1016/s0300-483x(99)00036-0.