PMID- 10414350
OWN - NLM
STAT- MEDLINE
DCOM- 19990812
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 868
DP  - 1999 Apr 30
TI  - Activity-dependent regulation of GABAA receptors.
PG  - 654-66
AB  - GABAA receptor heterogeneity is based on the combinatorial assembly of a large 
      family of subunits into distinct receptor subtypes. A neuron-specific expression 
      pattern of receptor subtypes has been demonstrated in adult rat brain, which can 
      be reproduced in vitro in primary neuron cultures. This suggests that genetic 
      programs established during ontogeny govern the expression of gamma-aminobutyric 
      acid (GABAA) receptor subtypes. Activity-dependent mechanisms nevertheless 
      modulate on a short-term basis the cell surface expression of GABAA receptors, as 
      demonstrated in cultured hippocampal neurons upon blockade of synaptic 
      transmission or application of brain-derived neurotrophic factor. Preliminary 
      evidence points to changes in protein phosphorylation as a mechanism underlying 
      short-term activity-dependent regulation of GABAA receptors. In vivo, chronic 
      pharmacological modulation of neuronal activity during development, while having 
      marked effects on the rate of cortical growth, failed to influence the expression 
      of GABAA receptor subtypes, suggesting that additional factors are involved.
FAU - Penschuck, S
AU  - Penschuck S
AD  - Institute of Pharmacology, University of Zurich, Switzerland.
FAU - Paysan, J
AU  - Paysan J
FAU - Giorgetta, O
AU  - Giorgetta O
FAU - Fritschy, J M
AU  - Fritschy JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cells, Cultured
MH  - Dizocilpine Maleate/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Fluorescent Antibody Technique
MH  - Geniculate Bodies/metabolism
MH  - Hippocampus/metabolism
MH  - Neurons/metabolism
MH  - Phosphorylation
MH  - Rats
MH  - Receptors, GABA-A/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/metabolism
MH  - Tetrodotoxin/pharmacology
EDAT- 1999/07/22 00:00
MHDA- 1999/07/22 00:01
CRDT- 1999/07/22 00:00
PHST- 1999/07/22 00:00 [pubmed]
PHST- 1999/07/22 00:01 [medline]
PHST- 1999/07/22 00:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb11342.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Apr 30;868:654-66. doi: 
      10.1111/j.1749-6632.1999.tb11342.x.