PMID- 10414507
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20190722
IS  - 0046-8177 (Print)
IS  - 0046-8177 (Linking)
VI  - 30
IP  - 7
DP  - 1999 Jul
TI  - The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia.
PG  - 864-8
AB  - A case of chronic eosinophilic leukemia (CEL) manifesting as spinal cord 
      compression by an extradural eosinophilic chloroma in a 32-year-old Chinese man 
      was presented, who subsequently developed extramedullary transformation at the 
      skin and then peritoneal cavity. Cytogenetic study of bone marrow cells at 
      diagnosis showed a clonal karyotypic abnormality of trisomy 8 (+8), which on 
      fluorescence in situ hybridization (FISH) was shown to be present in a clone of 
      abnormal eosinophils, hence showing the neoplastic nature of the eosinophilic 
      proliferation. There was another population of abnormal eosinophils that did not 
      show +8. At blastic transformation, all blast cells in ascitic fluid were shown 
      by FISH to harbor +8. These findings suggest that +8 in this case may have arisen 
      from clonal evolution and is not the primary genetic event in leukemogenesis, but 
      +8 most probably imparts a further survival advantage to the clone responsible 
      for subsequent blastic transformation.
FAU - Ma, S K
AU  - Ma SK
AD  - Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong 
      Kong.
FAU - Kwong, Y L
AU  - Kwong YL
FAU - Shek, T W
AU  - Shek TW
FAU - Wan, T S
AU  - Wan TS
FAU - Chow, E Y
AU  - Chow EY
FAU - Chan, J C
AU  - Chan JC
FAU - Chan, L C
AU  - Chan LC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Ascites/genetics/pathology
MH  - Biomarkers, Tumor/metabolism
MH  - *Chromosomes, Human, Pair 8
MH  - Chronic Disease
MH  - Humans
MH  - Hypereosinophilic Syndrome/diagnostic imaging/*genetics/metabolism
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Peritoneal Diseases/metabolism/pathology
MH  - Skin Diseases/metabolism/pathology
MH  - Tomography, X-Ray Computed
MH  - *Trisomy
EDAT- 1999/07/22 00:00
MHDA- 1999/07/22 00:01
CRDT- 1999/07/22 00:00
PHST- 1999/07/22 00:00 [pubmed]
PHST- 1999/07/22 00:01 [medline]
PHST- 1999/07/22 00:00 [entrez]
AID - S0046-8177(99)90149-1 [pii]
AID - 10.1016/s0046-8177(99)90149-1 [doi]
PST - ppublish
SO  - Hum Pathol. 1999 Jul;30(7):864-8. doi: 10.1016/s0046-8177(99)90149-1.