PMID- 10415379
OWN - NLM
STAT- MEDLINE
DCOM- 19990928
LR  - 20231213
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 835
IP  - 2
DP  - 1999 Jul 24
TI  - Effects of orphanin FQ on endomorphin-1 induced analgesia.
PG  - 241-6
AB  - Orphanin FQ (also known as nociceptin) is a 17-amino-acid peptide which acts as a 
      potent endogenous agonist of the orphan opioid receptor-like (ORL1) receptor. 
      Endomorphin-1, a 4-amino-acid peptide discovered recently, is a potent and 
      selective endogenous agonist for the mu-opiate receptor. In the present study, 
      the effect of OFQ or/and endomorphin-1 on the response to noxious thermal stimuli 
      was observed using the tail-flick test in rats. Intracerebroventricular (i.c.v.) 
      administration of OFQ (1, 5 microg) could shorten tail-flick latency; In 
      contrast, intrathecal (i.t.) administration of OFQ (1, 2 or 10 microg) could 
      increase the latency; i.c.v. (1, 2, 5 microg) or i.t. (0.2, 2, 5 microg) 
      administration of endomorphin-1 dose-dependently increased the latency, 
      indicating an analgesic effect. Furthermore, OFQ (0.1-5 microg) when 
      intraventricularly injected together with endomorphin-1 (5 microg), could 
      dose-dependently reverse the analgesia induced by the latter. On the contrary, 
      OFQ (1 microg) intrathecally injected together with endomorphin-1 (0.2 microg) 
      could further increase the tail-flick latency. The results showed that OFQ at the 
      supraspinal level produces hyperalgesia and is antagonistic to endomorphin-1, 
      while at the spinal level it produces analgesia and is synergic with 
      endomorphin-1. Different interaction mechanism between OFQ and endomorphin-1 in 
      the brain and the spinal cord is thus suggested.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Wang, Y Q
AU  - Wang YQ
AD  - State Key Laboratory of Neurobiology, Shanghai Medical University, Shanghai, 
      200032, China.
FAU - Zhu, C B
AU  - Zhu CB
FAU - Wu, G C
AU  - Wu GC
FAU - Cao, X D
AU  - Cao XD
FAU - Wang, Y
AU  - Wang Y
FAU - Cui, D F
AU  - Cui DF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Oligopeptides)
RN  - 0 (Opioid Peptides)
RN  - 0 (Receptors, Opioid)
RN  - 0 (endomorphin 1)
SB  - IM
MH  - Analgesics, Opioid/*pharmacology
MH  - Animals
MH  - Injections, Intraventricular
MH  - Injections, Spinal
MH  - Oligopeptides/*pharmacology
MH  - Opioid Peptides/*pharmacology
MH  - Pain/*drug therapy
MH  - Pain Measurement
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/drug effects
MH  - Receptors, Opioid/*agonists
MH  - Nociceptin
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - S0006-8993(99)01589-9 [pii]
AID - 10.1016/s0006-8993(99)01589-9 [doi]
PST - ppublish
SO  - Brain Res. 1999 Jul 24;835(2):241-6. doi: 10.1016/s0006-8993(99)01589-9.