PMID- 10415381
OWN - NLM
STAT- MEDLINE
DCOM- 19990928
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 835
IP  - 2
DP  - 1999 Jul 24
TI  - Deprivation of endogenous brain-derived neurotrophic factor results in impairment 
      of spatial learning and memory in adult rats.
PG  - 259-65
AB  - Brain-derived neurotrophic factor (BDNF) is abundantly expressed in the 
      hippocampus and cerebral cortex and is involved in synaptic plasticity and 
      long-term potentiation (LTP). The present study was under taken to investigate 
      whether endogenous BDNF was required for spatial learning and memory in a rat 
      model. Antibodies to BDNF (anti-BDNF, n=7) or control immunoglobulin G (control, 
      n=6) were delivered into the rat brain continuously for 7 days with an osmotic 
      pump. The rats were then subjected to a battery of behavioral tests. The results 
      show that the average escape latencies in the BDNF antibody treated group were 
      dramatically longer than those of the control (F=13.3, p<0.001). The rats treated 
      with control IgG swam for a significantly longer distance in the P quadrant 
      (where the escape plane had been placed) compared with the other three quadrants 
      (p<0.05). In contrast, anti-BDNF-treated rats swam an equivalent distance in all 
      four quadrants. The average percentage of swimming distance in the P quadrant by 
      anti-BDNF-treated rats was much less than that by control IgG treated rats 
      (p<0.001). These results suggest that endogenous BDNF is required for spatial 
      learning and memory in adult rats.
CI  - Copyright 1999 Elsevier Science B. V.
FAU - Mu, J S
AU  - Mu JS
AD  - Department of Neurology, Nanfang Hospital, First Military Medical University, 
      Guangzhou, 510515, China.
FAU - Li, W P
AU  - Li WP
FAU - Yao, Z B
AU  - Yao ZB
FAU - Zhou, X F
AU  - Zhou XF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*deficiency
MH  - Cues
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory Disorders/*physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spatial Behavior/*physiology
MH  - Swimming/physiology
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - S0006-8993(99)01592-9 [pii]
AID - 10.1016/s0006-8993(99)01592-9 [doi]
PST - ppublish
SO  - Brain Res. 1999 Jul 24;835(2):259-65. doi: 10.1016/s0006-8993(99)01592-9.