PMID- 10416032
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20191024
IS  - 0951-6433 (Print)
IS  - 0951-6433 (Linking)
VI  - 9
IP  - 2-4
DP  - 1999
TI  - Mitochondrial coenzyme Q content and aging.
PG  - 199-205
AB  - The main objective of this study was to determine the nature of the relationship 
      between aging and mitochondrial coenzyme Q (CoQ) content. Mitochondria in the 
      heart, skeletal muscle, kidney and brain of the mouse varied in both the amount 
      of total CoQ (CoQ9 + CoQ10) content as well as in the ratio of the CoQ9 to CoQ10. 
      CoQ content declined with age only in the skeletal muscle. Caloric restriction 
      (CR) resulted in an increase in the amount of CoQ9 in skeletal muscle 
      mitochondria. This effect was partially reversible upon termination of the 
      caloric restriction regimen. Results suggest that a decrease in mitochondrial CoQ 
      content is an integral aspect of aging in skeletal muscle.
FAU - Lass, A
AU  - Lass A
AD  - Department of Biological Sciences, Southern Methodist University, Dallas, TX 
      75275, USA.
FAU - Kwong, L
AU  - Kwong L
FAU - Sohal, R S
AU  - Sohal RS
LA  - eng
GR  - R01 AG13563/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Coenzymes)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - MGW7TYF2DQ (ubiquinone 9)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Brain/growth & development/metabolism
MH  - Coenzymes
MH  - Heart/growth & development
MH  - Kidney/growth & development/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitochondria/*metabolism
MH  - Mitochondria, Heart/metabolism
MH  - Mitochondria, Muscle/metabolism
MH  - Muscle Development
MH  - Muscle, Skeletal/growth & development
MH  - Organ Specificity
MH  - Ubiquinone/analogs & derivatives/*metabolism
EDAT- 1999/07/23 00:00
MHDA- 1999/07/23 00:01
CRDT- 1999/07/23 00:00
PHST- 1999/07/23 00:00 [pubmed]
PHST- 1999/07/23 00:01 [medline]
PHST- 1999/07/23 00:00 [entrez]
AID - 10.1002/biof.5520090215 [doi]
PST - ppublish
SO  - Biofactors. 1999;9(2-4):199-205. doi: 10.1002/biof.5520090215.