PMID- 10417365
OWN - NLM
STAT- MEDLINE
DCOM- 19991013
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 107
IP  - 8
DP  - 1999 Aug
TI  - Excretion of arsenic in urine as a function of exposure to arsenic in drinking 
      water.
PG  - 663-7
AB  - Urinary arsenic (As) concentrations were evaluated as a biomarker of exposure in 
      a U.S. population chronically exposed to inorganic As (InAs) in their drinking 
      water. Ninety-six individuals who consumed drinking water with As concentrations 
      of 8-620 microg/L provided first morning urine voids for up to 5 consecutive 
      days. The study population was 56% male, and 44% was younger than 18 years of 
      age. On one day of the study period, all voided urines were collected over a 
      24-hr period. Arsenic intake from drinking water was estimated from daily food 
      diaries. Comparison between the concentration of As in individual urine voids 
      with that in the 24-hr urine collection indicated that the concentration of As in 
      urine was stable throughout the day. Comparison of the concentration of As in 
      each first morning urine void over the 5-day study period indicated that there 
      was little day-to-day variation in the concentration of As in urine. The 
      concentration of As in drinking water was a better predictor of the concentration 
      of As in urine than was the estimated intake of As from drinking water. The 
      concentration of As in urine did not vary by gender. An age-dependent difference 
      in the concentration of As in urine may be attributed to the higher As dosage 
      rate per unit body weight in children than in adults. These findings suggest that 
      the analysis of a small number of urine samples may be adequate to estimate an 
      individual's exposure to InAs from drinking water and that the determination of 
      the concentration of InAs in a drinking water supply may be a useful surrogate 
      for estimating exposure to this metalloid.
FAU - Calderon, R L
AU  - Calderon RL
AD  - Human Studies Division, National Health and Environmental Effects Research 
      Laboratory, Research Triangle Park, North Carolina 27711, USA. 
      Calderon.Rebecca@epamail.epa.gov
FAU - Hudgens, E
AU  - Hudgens E
FAU - Le, X C
AU  - Le XC
FAU - Schreinemachers, D
AU  - Schreinemachers D
FAU - Thomas, D J
AU  - Thomas DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Biomarkers)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arsenic/adverse effects/*urine
MH  - Biomarkers
MH  - Child
MH  - Environmental Exposure/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Reproducibility of Results
MH  - *Water Supply
PMC - PMC1566491
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
PMCR- 1999/08/01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
PHST- 1999/08/01 00:00 [pmc-release]
AID - sc271_5_1835 [pii]
AID - 10.1289/ehp.99107663 [doi]
PST - ppublish
SO  - Environ Health Perspect. 1999 Aug;107(8):663-7. doi: 10.1289/ehp.99107663.