PMID- 10417662
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20190921
IS  - 0305-1846 (Print)
IS  - 0305-1846 (Linking)
VI  - 25
IP  - 3
DP  - 1999 Jun
TI  - Tenascin-R and C in multiple sclerosis lesions: relevance to extracellular matrix 
      remodelling.
PG  - 207-14
AB  - In the present study the distribution of the inhibitory extracellular molecules 
      tenascin-R (TN-R) and tenascin- C (TN-C) was examined by immunocytochemistry 
      during evolution of the multiple sclerosis (MS) lesion, in which astrogliosis is 
      a prominent feature. Sections were cut from five control cases and from 22 blocks 
      containing lesions representing different pathological stages in 18 cases of 
      secondary progressive MS. Widespread expression of TN-R was found in the normal 
      human central nervous system (CNS), while that of TN-C was in general restricted 
      to white matter. In acute MS plaques however, there was a similar striking loss 
      of both TN-R and TN-C up to the edge of the lesion, where the macrophage density 
      is greatest, extending into the apparently normal white matter. In subacute 
      lesions a TN-C and/or TN-R-immunopositive reactive astrocyte subpopulation was 
      prominent, reflecting synthesis of extracellular matrix molecules. Both tenascins 
      were expressed throughout chronic MS plaques at levels similar to those seen in 
      adjacent white matter. The loss of TN-R and TN-C in acute plaques is indicative 
      of enzyme-mediated breakdown of the matrix which may be a marker of blood-brain 
      barrier breakdown and leucocyte extravasation. Subsequent production of tenascins 
      by reactive astrocytes may result in glial scar formation impeding remyelination 
      and axonal repair in MS lesions.
FAU - Gutowski, N J
AU  - Gutowski NJ
AD  - The Multiple Sclerosis Laboratory, Institute of Neurology, London, UK.
FAU - Newcombe, J
AU  - Newcombe J
FAU - Cuzner, M L
AU  - Cuzner ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropathol Appl Neurobiol
JT  - Neuropathology and applied neurobiology
JID - 7609829
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Tenascin)
RN  - 147604-77-1 (tenascin R)
SB  - IM
MH  - Adult
MH  - Astrocytes/metabolism/pathology/ultrastructure
MH  - Cell Adhesion Molecules/*metabolism
MH  - Central Nervous System/pathology/ultrastructure
MH  - Extracellular Matrix/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*metabolism/*pathology
MH  - Tenascin/*metabolism
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - nan176 [pii]
AID - 10.1046/j.1365-2990.1999.00176.x [doi]
PST - ppublish
SO  - Neuropathol Appl Neurobiol. 1999 Jun;25(3):207-14. doi: 
      10.1046/j.1365-2990.1999.00176.x.