PMID- 10417677
OWN - NLM
STAT- MEDLINE
DCOM- 19990917
LR  - 20190915
IS  - 0141-9838 (Print)
IS  - 0141-9838 (Linking)
VI  - 21
IP  - 8
DP  - 1999 Aug
TI  - Cytokine and chemokine secretion by human peripheral blood cells in response to 
      viable Echinococcus multilocularis metacestode vesicles.
PG  - 433-8
AB  - In human alveolar echinococcosis, asexually proliferating metacestodes of 
      Echinococcus multilocularis progressively infiltrate host tissues and cause 
      serious pathology to the affected organs. This study employed an in vitro culture 
      of E. multilocularis and examined the production of cytokines and chemokines by 
      peripheral blood cells from echinococcosis patients in response to viable 
      proliferating E. multilocularis metacestode vesicles (Em-vesicles). A significant 
      interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) production 
      was elicited in echinococcosis patients when their cells were cocultured with 
      viable Em-vesicles and autologous immune sera. Furthermore, in echinococcosis 
      patients, substantial amounts of cytokines were detected; and the levels of IL-12 
      and IL-13 found in patients correlated with the actual state of clinical disease. 
      These observations suggest that viable E. multilocularis vesicles will induce 
      significant cellular production of cytokines and chemokines in patients, and that 
      such immune mediators may activate and enhance antibody-dependent cellular 
      effector mechanism against proliferating metacestodes of E. multilocularis.
FAU - Dreweck, C M
AU  - Dreweck CM
AD  - Section of Infectious Diseases and Clinical Immunology, University of Ulm, 
      D-89081 Ulm, Germany.
FAU - Soboslay, P T
AU  - Soboslay PT
FAU - Schulz-Key, H
AU  - Schulz-Key H
FAU - Gottstein, B
AU  - Gottstein B
FAU - Kern, P
AU  - Kern P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Parasite Immunol
JT  - Parasite immunology
JID - 7910948
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-8)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antibody-Dependent Cell Cytotoxicity/drug effects
MH  - Cell Survival
MH  - Cells, Cultured/cytology/parasitology
MH  - Chemokines/blood/*metabolism
MH  - Cytokines/blood/*metabolism
MH  - Echinococcosis, Hepatic/blood/physiopathology
MH  - *Echinococcus
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interleukin-10/blood
MH  - Interleukin-12/blood
MH  - Interleukin-13/blood
MH  - Interleukin-8/analysis
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism/*parasitology
MH  - Neutrophils/metabolism/*parasitology
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - pim243 [pii]
AID - 10.1046/j.1365-3024.1999.00243.x [doi]
PST - ppublish
SO  - Parasite Immunol. 1999 Aug;21(8):433-8. doi: 10.1046/j.1365-3024.1999.00243.x.