PMID- 10417859
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20191103
IS  - 1381-3455 (Print)
IS  - 1381-3455 (Linking)
VI  - 106
IP  - 4
DP  - 1998 Oct
TI  - Effects of halothane on mechanical response of skeletal muscle from malignant 
      hyperthermia susceptible patients.
PG  - 318-24
AB  - The purpose of this investigation was to compare the effects of halothane on 
      malignant hyperthermia (MH) and normal isolated muscle bundle performance during 
      isometric contraction and relaxation phases. Mechanical parameters were measured: 
      peak tension (PT), time to peak tension (TPT) and positive peak of isometric 
      tension derivative (+dP/dtmax) characterized the contraction phase. 
      Half-relaxation time (RT1/2) and negative peak of isometric tension derivative 
      (-dP/dtmax) characterized the relaxation phase. The ratio R = 
      (+dP/dtmax)/(-dP/dtmax) was used to study the coupling between contraction and 
      relaxation under isometric condition. In normal muscle, halothane increased PT by 
      nearly 40% without altering TPT. The +dP/dtmax value increased concomitantly with 
      the -dP/dtmax values, thus no changes in R was observed. In MH muscle, PT was 
      first potentiated (0.5-1.0 vol% halothane) and then depressed (2.0-3.0 vol% 
      halothane). TPT and +dP/dtmax were not altered whereas RT1/2 increased 
      progressively with concomitant decrease in -dP/dtmax, thus R increased by nearly 
      40%. The amplitude of MH muscle contracture with stepwise concentrations of 
      halothane was correlated with the increase of RT1/2 and R, and the decrease of 
      -dP/dtmax. These results suggest that halothane alters the relaxation phase more 
      than the contraction phase in MH human skeletal muscle compared to normal muscle.
FAU - Etchrivi, T S
AU  - Etchrivi TS
AD  - Laboratoire d'Anesthesie et de Medecine d'Urgence, Laboratoire de Pharmacologie, 
      Faculte de Medecine, Universite de Lille II, France.
FAU - Adnet, P J
AU  - Adnet PJ
FAU - Tavernier, B
AU  - Tavernier B
FAU - Diallo, A
AU  - Diallo A
FAU - Haudecoeur, G
AU  - Haudecoeur G
FAU - Krivosic-Horber, R M
AU  - Krivosic-Horber RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Anesthetics, Inhalation)
RN  - 3G6A5W338E (Caffeine)
RN  - UQT9G45D1P (Halothane)
SB  - IM
MH  - Anesthetics, Inhalation/*pharmacology
MH  - Biopsy
MH  - Caffeine/pharmacology
MH  - Disease Susceptibility/*diagnosis
MH  - Halothane/*pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - *Malignant Hyperthermia
MH  - Membrane Potentials/drug effects
MH  - Muscle Contraction/drug effects
MH  - Muscle, Skeletal/*drug effects/pathology
EDAT- 1999/07/27 00:00
MHDA- 1999/07/27 00:01
CRDT- 1999/07/27 00:00
PHST- 1999/07/27 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1999/07/27 00:00 [entrez]
AID - 10.1076/apab.106.4.318.4375 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 1998 Oct;106(4):318-24. doi: 10.1076/apab.106.4.318.4375.