PMID- 10420923
OWN - NLM
STAT- MEDLINE
DCOM- 19991021
LR  - 20091119
IS  - 0556-6177 (Print)
IS  - 0556-6177 (Linking)
VI  - 41
IP  - 3
DP  - 1997 Jul-Sep
TI  - [Neurotrophins. I: Molecular features].
PG  - 173-9
AB  - Neurotrophic factors are proteins necessary for neuronal development and 
      survival. The first isolated and characterized neurotrophin was nerve growth 
      factor (NGF). Other structurally related neurotrophins are brain-derived 
      neurotrophic factor (BDNF) and the neurotrophins NT-3, NT-4/5 and NT-6. The 
      neurotrophins bind to specific tyrosine-kinase (trk) receptors, which are 
      transmembrane proteins with intrinsic phosphorylating activity. Three trk 
      receptor subtypes are known at present, trk A, trk B and trk C, which 
      preferentially bind NGF, BDNF and NT-3 respectively. All of the neurotrophins 
      bind to another low-affinity receptor called p75. The neurotrophins are generally 
      synthesized in target cells and, after receptor binding, are transported 
      retrogradely from the nerve terminal to the nucleus where they regulate gene 
      expression. The role of neurotrophins in development has been further 
      characterized by means of gene disruption studies that show profound phenotype 
      alterations in mice lacking any of the trk receptors.
FAU - Zazpe, A
AU  - Zazpe A
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad de Navarra.
FAU - Del Rio, J
AU  - Del Rio J
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Neurotrofinas. I: Aspectos moleculares.
PL  - Spain
TA  - Rev Med Univ Navarra
JT  - Revista de medicina de la Universidad de Navarra
JID - 0123071
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Abnormalities, Multiple/genetics
MH  - Animals
MH  - Enzyme Activation
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Neurologic Mutants
MH  - Nerve Growth Factors/chemistry/genetics/metabolism/*physiology
MH  - Nervous System Malformations/genetics
MH  - Neurons/metabolism
MH  - Phosphorylation
MH  - Protein Conformation
MH  - Protein Processing, Post-Translational
MH  - Proto-Oncogene Proteins/deficiency/genetics/metabolism
MH  - Receptor Protein-Tyrosine Kinases/deficiency/genetics/metabolism
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkA
MH  - Receptor, trkC
MH  - Receptors, Nerve Growth Factor/deficiency/genetics/metabolism
RF  - 34
EDAT- 1997/07/01 00:00
MHDA- 1999/07/27 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1999/07/27 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PST - ppublish
SO  - Rev Med Univ Navarra. 1997 Jul-Sep;41(3):173-9.