PMID- 10421794
OWN - NLM
STAT- MEDLINE
DCOM- 19991004
LR  - 20220408
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 5
IP  - 8
DP  - 1999 Aug
TI  - Monocyte chemotactic protein-1 expression in human corpus luteum.
PG  - 697-702
AB  - Invasion of the corpus luteum by macrophages is a characteristic of luteal 
      regression. Monocyte chemotactic protein-1 (MCP-1), a chemokine that recruits 
      macrophages, is expressed in the rat corpus luteum where it increases in amount 
      during luteolysis. In this study we examined the temporal and spatial expression 
      of MCP-1 and changes in macrophage concentration in the human corpus luteum. 
      Corpora lutea (n = 39) were grouped according to menstrual cycle phase and were 
      examined by immunohistochemistry for MCP-1 and macrophages, and by Northern blot 
      for MCP-1 mRNA. We found increasing amounts of macrophages with progressing 
      luteolysis (P < 0.001). Staining for MCP-1 was stronger in the regressing corpora 
      lutea compared with the staining in corpora lutea of early luteal phase (P < 
      0.05). MCP-1 was more prominent in blood vessel walls surrounding the corpus 
      luteum than in vessels located far from it. The mean MCP-1 mRNA expression in 
      regressing corpora lutea was higher than that observed in corpora lutea of the 
      early and mid-luteal phase (P = 0.003). In conclusion, we found that MCP-1 
      expression and the number of macrophages increase with regression of the corpus 
      luteum. MCP-1 is mostly expressed in blood vessel walls surrounding the corpus 
      luteum and may play a role in the recruitment of macrophages to the corpus luteum 
      during its regression.
FAU - Senturk, L M
AU  - Senturk LM
AD  - Department of Obstetrics and Gynecology and Department of Pathology, Yale 
      University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA.
FAU - Seli, E
AU  - Seli E
FAU - Gutierrez, L S
AU  - Gutierrez LS
FAU - Mor, G
AU  - Mor G
FAU - Zeyneloglu, H B
AU  - Zeyneloglu HB
FAU - Arici, A
AU  - Arici A
LA  - eng
GR  - HD 01041/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Probes)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Base Sequence
MH  - Blood Vessels/metabolism
MH  - Blotting, Northern
MH  - Cell Count
MH  - Chemokine CCL2/*genetics/*metabolism
MH  - Corpus Luteum/blood supply/*metabolism
MH  - DNA Probes/genetics
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - Luteolysis/genetics/physiology
MH  - Macrophages/cytology/physiology
MH  - Middle Aged
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - 10.1093/molehr/5.8.697 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 1999 Aug;5(8):697-702. doi: 10.1093/molehr/5.8.697.