PMID- 10422744
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 54 Suppl 49
DP  - 1999
TI  - Recognizing early asthma.
PG  - 24-8
AB  - Asthma symptoms often develop during the first years of life. Longitudinal 
      studies show that at least 40% of children with wheezing lower respiratory 
      illnesses (LRIs) during the first 3 years of life still have wheezing episodes at 
      6 years of age. Thus, it is important to identify children at risk of developing 
      asthma, and to distinguish these from those in whom early wheezing is likely to 
      be transient. This is complicated, however, by the variable nature of asthma and 
      the lack of specific and sensitive markers. Genetic markers and epidemiologic 
      risk factors for asthma have been identified, but cannot be used to predict the 
      development of asthma in an individual patient. Similarly, infants who 
      subsequently develop asthma in childhood have higher serum immunoglobulin E (IgE) 
      and peripheral eosinophil counts than those who do not develop asthma, but, 
      again, these factors are not sufficiently sensitive and specific to allow 
      identification of children at risk of developing asthma. An algorithm is 
      presented that outlines possible criteria to determine the risk of developing 
      asthma in infants.
FAU - Martinez, F D
AU  - Martinez FD
AD  - College of Medicine, University of Arizona, Tucson, USA.
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Genetic Markers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Algorithms
MH  - Asthma/*diagnosis/genetics/immunology/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Eosinophils/immunology
MH  - Genetic Markers
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Longitudinal Studies
MH  - Respiratory Tract Diseases/complications/genetics/immunology
MH  - Risk Factors
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - 10.1111/j.1398-9995.1999.tb04384.x [doi]
PST - ppublish
SO  - Allergy. 1999;54 Suppl 49:24-8. doi: 10.1111/j.1398-9995.1999.tb04384.x.