PMID- 10423138
OWN - NLM
STAT- MEDLINE
DCOM- 19990810
LR  - 20200217
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 80 ( Pt 7)
DP  - 1999 Jul
TI  - Restricted Theiler's murine encephalomyelitis virus infection in murine 
      macrophages induces apoptosis.
PG  - 1701-1705
LID - 10.1099/0022-1317-80-7-1701 [doi]
AB  - Increasing evidence suggests that macrophages (M(phi)s) are necessary for 
      persistence of Theiler's murine encephalomyelitis virus (TMEV) in the mouse 
      central nervous system. Analysis of BeAn virus infection in the Mphi cell lines 
      P388D1, J774A.1 and PU5-1.8, which are intermediate in their state of 
      differentiation and resemble multifunctional resident M(phi)s, revealed 
      restricted TMEV growth. As a result of the restricted infection, these Mphi cell 
      lines were induced to undergo apoptosis as demonstrated by cellular morphology, 
      DNA fragmentation, caspase protease activity, and in individual cells, by 
      terminal deoxytransferase dUTP nick-end labelling (TUNEL).
FAU - Jelachich, M L
AU  - Jelachich ML
FAU - Lipton, H L
AU  - Lipton HL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Cardiovirus Infections/enzymology/*pathology/virology
MH  - Caspases/metabolism
MH  - DNA Fragmentation
MH  - Enzyme Activation
MH  - In Situ Nick-End Labeling
MH  - Macrophages/enzymology/*pathology/*virology
MH  - Mice
MH  - *Theilovirus
EDAT- 1999/07/28 00:00
MHDA- 1999/07/28 00:01
CRDT- 1999/07/28 00:00
PHST- 1999/07/28 00:00 [pubmed]
PHST- 1999/07/28 00:01 [medline]
PHST- 1999/07/28 00:00 [entrez]
AID - 10.1099/0022-1317-80-7-1701 [doi]
PST - ppublish
SO  - J Gen Virol. 1999 Jul;80 ( Pt 7):1701-1705. doi: 10.1099/0022-1317-80-7-1701.