PMID- 10423347
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20131121
IS  - 0022-2828 (Print)
IS  - 0022-2828 (Linking)
VI  - 31
IP  - 8
DP  - 1999 Aug
TI  - Increased plasma nitrite level in cardiac failure.
PG  - 1495-500
AB  - Increased Plasma Nitrite Level in Cardiac Failure. Nitric oxide is implicated in 
      the pathogenesis of cardiac failure. Plasma nitrite level (an end product of 
      nitric oxide metabolism) is studied in 15 patients of chronic rheumatic valvular 
      heart disease with myocardial contractile dysfunction and cardiac failure (Group 
      I), 15 patients of chronic rheumatic valvular heart disease with similar valvular 
      lesions, normal myocardial contractile function and without cardiac failure 
      (Group II) and 15 healthy controls (Group III). Patients in Group I had higher 
      nitrite level (242.2+/-31.7 n m) compared to Group II (142.6+/-24.4 n m) and 
      Group III (102.7+/-15.9 n m). Among the patients with rheumatic heart disease, 
      increasing nitrite level correlated significantly with worsening of contractile 
      function [Nitrite v End systolic volume/Body surface area (T(xy.z)=0.23), Nitrite 
      v End systolic dimension/Body surface area (T(xy.z)=0.32), Nitrite v left 
      ventricular ejection fraction (T(xy.z)=-0.24), Nitrite v tricuspid annular plane 
      systolic excursion (T(xy.z)=-0. 29)] and worsening New York Heart Association 
      (NYHA) functional class (r(s)=0.5). We conclude that plasma nitrite, a stable end 
      product of nitric oxide metabolism is increased in patients of rheumatic valvular 
      heart disease with cardiac failure, suggesting increased nitric oxide production. 
      Increased level of nitric oxide might be playing a significant role in myocardial 
      contractile dysfunction and alteration of vascular response in cardiac failure.
CI  - Copyright 1999 Academic Press.
FAU - Ramesh, G
AU  - Ramesh G
AD  - Department of Cardiology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh-160012, India.
FAU - Varma, J S
AU  - Varma JS
FAU - Ganguly, N K
AU  - Ganguly NK
FAU - Dhawan, V
AU  - Dhawan V
FAU - Bali, H K
AU  - Bali HK
FAU - Singh, M
AU  - Singh M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Mol Cell Cardiol
JT  - Journal of molecular and cellular cardiology
JID - 0262322
RN  - 0 (Nitrites)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Myocardial Contraction
MH  - Nitric Oxide/metabolism
MH  - Nitrites/*blood
MH  - Rheumatic Heart Disease/*blood/physiopathology
EDAT- 1999/07/29 00:00
MHDA- 1999/07/29 00:01
CRDT- 1999/07/29 00:00
PHST- 1999/07/29 00:00 [pubmed]
PHST- 1999/07/29 00:01 [medline]
PHST- 1999/07/29 00:00 [entrez]
AID - S0022282899909823 [pii]
AID - 10.1006/jmcc.1999.0982 [doi]
PST - ppublish
SO  - J Mol Cell Cardiol. 1999 Aug;31(8):1495-500. doi: 10.1006/jmcc.1999.0982.