PMID- 10425240
OWN - NLM
STAT- MEDLINE
DCOM- 19990921
LR  - 20220331
IS  - 0034-5288 (Print)
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 67
IP  - 1
DP  - 1999 Aug
TI  - Differential production of proinflammatory cytokines in the pig lung during 
      different respiratory virus infections: correlations with pathogenicity.
PG  - 47-52
AB  - The acute stages of infection with swine influenza virus (SIV), porcine 
      respiratory coronavirus (PRCV) and porcine reproductive-respiratory syndrome 
      virus (PRRSV) were shown to differ in terms of clinical and lung inflammatory 
      effects and proinflammatory cytokine profiles in bronchoalveolar lavage (BAL) 
      fluids. Caesarian-derived colostrum-deprived pigs were inoculated intratracheally 
      with one of the three viruses. SIV infection was followed within 1 day post 
      inoculation (d PI) by characteristic respiratory and general signs, and excessive 
      lung epithelial desquamation and neutrophil infiltration (38 to 56 per cent of 
      BAL cells at 1 d PI vs 0 to 1 per cent in controls). High concentrations of 
      bioactive interferon-alpha (IFN -alpha), tumour necrosis factor-alpha (TNF 
      -alpha) and interleukin-1 (IL -1) coincided with peak symptoms and neutrophil 
      infiltration. PRCV infection was asymptomatic and produced a mild 
      bronchointerstitial pneumonitis and neutrophil infiltration (13 to 22 per cent of 
      BAL cells at 4 d PI). IFN -alpha titres parallelled those found during SIV 
      infection, TNF -alpha was negligible and IL -1 undetectable. PRRSV infection 
      induced anorexia and lethargy between 3 and 5 d PI. There was marked infiltration 
      with mononuclear cells in alveolar septa and BAL fluids between 7 and 10 d PI, 
      while neutrophils remained at less than 11 per cent of BAL cells at any time. IL 
      -1 was produced from three throughout 10 d PI, while IFN -alpha production was 
      minimal and TNF -alpha undetectable. These data strongly suggest that 
      proinflammatory cytokines can be important mediators of viral respiratory 
      disease.
CI  - Copyright 1999 Harcourt Publishers Ltd.
FAU - Van Reeth, K
AU  - Van Reeth K
AD  - Laboratory of Veterinary Virology, Faculty of Veterinary Medicine, Salisburglaan, 
      Merelbeke, B-9820, Belgium.
FAU - Labarque, G
AU  - Labarque G
FAU - Nauwynck, H
AU  - Nauwynck H
FAU - Pensaert, M
AU  - Pensaert M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid
MH  - Coronavirus/pathogenicity/physiology
MH  - Coronavirus Infections/metabolism/*veterinary/virology
MH  - Cytokines/*biosynthesis
MH  - Influenza A virus/pathogenicity/physiology
MH  - Lung/metabolism/*virology
MH  - Orthomyxoviridae Infections/metabolism/*veterinary/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*metabolism
MH  - Porcine respiratory and reproductive syndrome virus/pathogenicity/physiology
MH  - Swine
MH  - Swine Diseases/*metabolism/*virology
MH  - Virus Replication
PMC - PMC7126504
EDAT- 1999/07/30 00:00
MHDA- 1999/07/30 00:01
PMCR- 2002/05/25
CRDT- 1999/07/30 00:00
PHST- 1999/07/30 00:00 [pubmed]
PHST- 1999/07/30 00:01 [medline]
PHST- 1999/07/30 00:00 [entrez]
PHST- 2002/05/25 00:00 [pmc-release]
AID - S0034-5288(98)90277-6 [pii]
AID - 10.1053/rvsc.1998.0277 [doi]
PST - ppublish
SO  - Res Vet Sci. 1999 Aug;67(1):47-52. doi: 10.1053/rvsc.1998.0277.