PMID- 10426318
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20171116
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 5
IP  - 8
DP  - 1999 Aug
TI  - Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 
      'killer' dendritic cells.
PG  - 930-7
AB  - Dendritic cells (DCs) are special subsets of antigen-presenting cells 
      characterized by their highly potent capacity to activate immunologically naive T 
      cells. Here we report that DCs that are transfected with CD95 ligand (CD95L) 
      cDNA, called 'killer' DCs, deliver death signals, instead of activation signals, 
      to T cells after antigen-specific interaction. Injection of antigen-pulsed killer 
      DCs into mice before sensitization induced antigen-specific immunosuppression. 
      When administered after sensitization, killer DCs suppressed immune responses 
      almost completely after subsequent challenge. Thus, killer DCs represent an 
      entirely new immunomodulatory protocol, which may become directly applicable in 
      preventing and even treating T cell-mediated inflammatory diseases.
FAU - Matsue, H
AU  - Matsue H
AD  - Department of Dermatology, University of Texas Southwestern Medical Center, 
      Dallas 75235-9069, USA.
FAU - Matsue, K
AU  - Matsue K
FAU - Walters, M
AU  - Walters M
FAU - Okumura, K
AU  - Okumura K
FAU - Yagita, H
AU  - Yagita H
FAU - Takashima, A
AU  - Takashima A
LA  - eng
GR  - R01-AI43262/AI/NIAID NIH HHS/United States
GR  - R01-AR35068/AR/NIAMS NIH HHS/United States
GR  - R01-AR43777/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (DNA, Complementary)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fasl protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (fas Receptor)
RN  - 9006-59-1 (Ovalbumin)
RN  - D241E059U6 (Dinitrofluorobenzene)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - Apoptosis/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Line
MH  - Cell Transplantation
MH  - Clone Cells/immunology
MH  - DNA, Complementary/genetics
MH  - Dendritic Cells/cytology/*immunology
MH  - Dermatitis, Allergic Contact/immunology
MH  - Dinitrofluorobenzene
MH  - Fas Ligand Protein
MH  - Female
MH  - Hypersensitivity, Delayed/immunology
MH  - *Immune Tolerance
MH  - Immunity, Cellular/genetics
MH  - Liver/drug effects
MH  - Membrane Glycoproteins/*genetics/*immunology
MH  - Mice
MH  - Ovalbumin/immunology
MH  - Transfection
MH  - fas Receptor/immunology
EDAT- 1999/07/30 10:00
MHDA- 2001/03/23 10:01
CRDT- 1999/07/30 10:00
PHST- 1999/07/30 10:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/07/30 10:00 [entrez]
AID - 10.1038/11375 [doi]
PST - ppublish
SO  - Nat Med. 1999 Aug;5(8):930-7. doi: 10.1038/11375.