PMID- 10429688
OWN - NLM
STAT- MEDLINE
DCOM- 19990817
LR  - 20151119
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 212
IP  - 2
DP  - 1999 Aug
TI  - Moyamoya disease: evaluation with diffusion-weighted and perfusion echo-planar MR 
      imaging.
PG  - 340-7
AB  - PURPOSE: To determine the clinical efficacy of diffusion-weighted and perfusion 
      echo-planar magnetic resonance (MR) imaging in the evaluation of moyamoya 
      disease. MATERIALS AND METHODS: Seventeen patients with moyamoya disease were 
      examined prospectively with diffusion-weighted and perfusion echo-planar MR 
      imaging and conventional angiography. The change in the effective transverse 
      relaxation rate (delta R2*) peak value, delta R2* peak time, and delta R2* 
      integral were calculated to assess regional cerebral perfusion. The MR images 
      were compared with angiographic images. RESULTS: Of the 34 posterior cerebral 
      arteries (PCAs) of the 17 patients, 14 PCAs (41%) in 11 patients showed stenosis 
      or occlusion. The delta R2* peak value ratio in the cerebral hemispheres 
      decreased significantly, and the delta R2* peak time ratio increased 
      significantly, with PCA stenosis and occlusion. However, no correlation was 
      apparent between perfusion and extent of the stenotic or occlusive lesions of the 
      internal carotid artery bifurcation. The frequency of cerebral infarctions was 
      significantly increased in patients with stenotic or occlusive PCA lesions. For 
      three acute infarctions, a decrease in the apparent diffusion coefficient was 
      significantly correlated with a decrease in the delta R2* peak value, an increase 
      in the delta R2* peak time, and a decrease in the delta R2* integral. CONCLUSION: 
      Regional cerebral perfusion in moyamoya disease is decreased and delayed with PCA 
      stenosis, with greater decrease and delay with PCA occlusion. Diffusion-weighted 
      and perfusion imaging are useful for evaluating cerebral ischemia in moyamoya 
      disease.
FAU - Yamada, I
AU  - Yamada I
AD  - Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental 
      University, Japan. yamada.crad@med.tmd.ac.jp
FAU - Himeno, Y
AU  - Himeno Y
FAU - Nagaoka, T
AU  - Nagaoka T
FAU - Akimoto, H
AU  - Akimoto H
FAU - Matsushima, Y
AU  - Matsushima Y
FAU - Kuroiwa, T
AU  - Kuroiwa T
FAU - Shibuya, H
AU  - Shibuya H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Brain/blood supply/pathology
MH  - Brain Ischemia/diagnosis
MH  - Cerebral Angiography
MH  - Contrast Media
MH  - Echo-Planar Imaging/*methods
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Moyamoya Disease/*diagnosis
MH  - Prospective Studies
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
AID - 10.1148/radiology.212.2.r99au08340 [doi]
PST - ppublish
SO  - Radiology. 1999 Aug;212(2):340-7. doi: 10.1148/radiology.212.2.r99au08340.