PMID- 10430361
OWN - NLM
STAT- MEDLINE
DCOM- 19990922
LR  - 20041117
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 46
IP  - 27
DP  - 1999 May-Jun
TI  - The significance of hepatitis G virus infection in patients with non-A to C 
      hepatic diseases.
PG  - 1870-3
AB  - The clinical significance of hepatitis G virus (HGV) infection was studied in 35 
      patients with various liver diseases of unknown etiology. Diseases included 5 
      cases of acute hepatitis, 23 cases of chronic liver diseases, and 7 cases of 
      hepatocellular carcinoma. None of the patients showed evidence of hepatitis A, B, 
      or C virus infection. HGV RNA was detected by reverse transcription polymerase 
      chain reaction (RT-PCR) within 5' untranslated region (5'UTR), nonstructure (NS) 
      3 region, and NS5 region. RT-PCR within 5'UTR and NS5 detected HGV RNA in 9 of 35 
      patients, while that within NS3 detected HGV RNA in only 2 patients. This result 
      suggests that RT-PCR within 5'UTR and NS5 as a primer is more sensitive than NS3 
      in Japanese patients. HGV RNA was detected in 3 of 5 cases of acute hepatitis, 3 
      of 23 cases of chronic liver diseases, and 1 of 7 cases of hepatocellular 
      carcinoma. The HGV positive rate was high in patients with acute hepatitis 
      suggesting that HGV might cause acute liver injury. In patients with chronic 
      liver injury, the elevation of serum ALT levels was mild for about 2 years, but 
      persistent HGV infection existed. The studied patients had no causative agent 
      except for HGV. Therefore, HGV was thought to be an important etiological agent 
      for liver injury.
FAU - Tanaka, T
AU  - Tanaka T
AD  - Liver Unit, Tokyo Metropolitan Komagome Hospital, Japan. 
      t-tanaka-k@komagome-hospital.bunkyo.tokyo.jp
FAU - Hess, G
AU  - Hess G
FAU - Tanaka, S
AU  - Tanaka S
FAU - Kohara, M
AU  - Kohara M
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/diagnosis/virology
MH  - Female
MH  - *Flaviviridae
MH  - Hepatitis A/*diagnosis/virology
MH  - Hepatitis B/*diagnosis/virology
MH  - Hepatitis C/*diagnosis/virology
MH  - Hepatitis, Chronic/diagnosis/virology
MH  - Hepatitis, Viral, Human/*diagnosis/virology
MH  - Humans
MH  - Liver Neoplasms/diagnosis/virology
MH  - Male
MH  - Middle Aged
MH  - RNA, Viral/blood
EDAT- 1999/08/03 00:00
MHDA- 1999/08/03 00:01
CRDT- 1999/08/03 00:00
PHST- 1999/08/03 00:00 [pubmed]
PHST- 1999/08/03 00:01 [medline]
PHST- 1999/08/03 00:00 [entrez]
PST - ppublish
SO  - Hepatogastroenterology. 1999 May-Jun;46(27):1870-3.