PMID- 10430952
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20230815
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 16
DP  - 1999 Aug 3
TI  - Neurotrophins: peripherally and centrally acting modulators of tactile 
      stimulus-induced inflammatory pain hypersensitivity.
PG  - 9385-90
AB  - Brain-derived neurotrophic factor (BDNF) is expressed in nociceptive sensory 
      neurons and transported anterogradely to the dorsal horn of the spinal cord where 
      it is located in dense core vesicles in C-fiber terminals. Peripheral 
      inflammation substantially up-regulates BDNF mRNA and protein in the dorsal root 
      ganglion (DRG) in a nerve growth factor-dependent fashion and results in novel 
      expression of BDNF by DRG neurons with myelinated axons. C-fiber electrical 
      activity also increases BDNF expression in the DRG, and both inflammation and 
      activity increase full-length TrkB receptor levels in the dorsal horn. 
      Sequestration of endogenous BDNF/neurotrophin 4 by intraspinal TrkB-Fc fusion 
      protein administration does not, in noninflamed animals, change basal pain 
      sensitivity nor the mechanical hypersensitivity induced by peripheral capsaicin 
      administration, a measure of C fiber-mediated central sensitization. TrkB-Fc 
      administration also does not modify basal inflammatory pain hypersensitivity, but 
      does block the progressive hypersensitivity elicited by low-intensity tactile 
      stimulation of inflamed tissue. BDNF, by virtue of its nerve growth factor 
      regulation in sensory neurons including novel expression in A fibers, has a role 
      as a central modulator of tactile stimulus-induced inflammatory pain 
      hypersensitivity.
FAU - Mannion, R J
AU  - Mannion RJ
AD  - Department of Anesthesia and Critical Care, Massachusetts General Hospital and 
      Harvard Medical School, Charlestown, MA 02129, USA.
FAU - Costigan, M
AU  - Costigan M
FAU - Decosterd, I
AU  - Decosterd I
FAU - Amaya, F
AU  - Amaya F
FAU - Ma, Q P
AU  - Ma QP
FAU - Holstege, J C
AU  - Holstege JC
FAU - Ji, R R
AU  - Ji RR
FAU - Acheson, A
AU  - Acheson A
FAU - Lindsay, R M
AU  - Lindsay RM
FAU - Wilkinson, G A
AU  - Wilkinson GA
FAU - Woolf, C J
AU  - Woolf CJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - R01 NS038253/NS/NINDS NIH HHS/United States
GR  - N38253-01/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Recombinant Fusion Proteins)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Axonal Transport
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Decerebrate State
MH  - Electric Stimulation
MH  - Ganglia, Spinal/physiology/physiopathology
MH  - *Gene Expression Regulation
MH  - In Situ Hybridization
MH  - Inflammation/*physiopathology
MH  - Male
MH  - Motor Neurons/physiology
MH  - Nerve Fibers/physiology
MH  - Neurons, Afferent/*physiology
MH  - Pain/*physiopathology
MH  - Physical Stimulation
MH  - Protein Biosynthesis
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/genetics/physiology
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/genetics/physiology
MH  - Recombinant Fusion Proteins/pharmacology
MH  - Spinal Cord/*physiology/physiopathology
MH  - Time Factors
MH  - Touch
MH  - Transcription, Genetic
PMC - PMC17792
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
PMCR- 2000/02/03
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
PHST- 2000/02/03 00:00 [pmc-release]
AID - 1354 [pii]
AID - 10.1073/pnas.96.16.9385 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9385-90. doi: 
      10.1073/pnas.96.16.9385.