PMID- 10431187
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20190915
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Linking)
VI  - 15
IP  - 8
DP  - 1999 Aug
TI  - Host resistance to infection: genetic control of lipopolysaccharide 
      responsiveness by TOLL-like receptor genes.
PG  - 291-4
AB  - Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory 
      response in the normal host. Through genetic analysis of mutant mice, the gene 
      encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical 
      component of this host defense mechanism. Tlr4 is a member of an ancient gene 
      family that regulates antimicrobial host defense in plants, invertebrates and 
      mammals.
FAU - Qureshi, S T
AU  - Qureshi ST
AD  - Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6. 
      cxqu@musica.mcgill.ca
FAU - Gros, P
AU  - Gros P
FAU - Malo, D
AU  - Malo D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
RN  - 0 (Drosophila Proteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Bacterial Infections/genetics/*immunology
MH  - Cloning, Molecular
MH  - *Drosophila Proteins
MH  - Lipopolysaccharides/*metabolism
MH  - Membrane Glycoproteins/*genetics/physiology
MH  - Mice
MH  - Multigene Family
MH  - Receptors, Cell Surface/*genetics/physiology
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
RF  - 24
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
AID - S0168-9525(99)01782-5 [pii]
AID - 10.1016/s0168-9525(99)01782-5 [doi]
PST - ppublish
SO  - Trends Genet. 1999 Aug;15(8):291-4. doi: 10.1016/s0168-9525(99)01782-5.