PMID- 10431712
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20210112
IS  - 0304-3959 (Print)
IS  - 0304-3959 (Linking)
VI  - 81
IP  - 3
DP  - 1999 Jun
TI  - Hyperalgesia due to nerve damage: role of nerve growth factor.
PG  - 245-255
LID - 10.1016/S0304-3959(99)00018-4 [doi]
AB  - The hypothesis that nerve growth factor (NGF) and brain-derived neurotrophic 
      factor (BDNF) contribute to hyperalgesia resulting from nerve damage was tested 
      in rats in which the sciatic nerve was partially transected on one side. 
      Administration of antisera raised against NGF and BDNF relieved mechanical and 
      thermal hyperalgesia in these animals. It has been suggested that NGF may elicit 
      hyperalgesia by inducing mast cells to release algesic agents such as serotonin 
      (5-HT). We found that degranulation of mast cells with compound 48/80 relieved 
      mechanical and thermal hyperalgesia produced by nerve damage. We also found that 
      local injection of the 5-HT2A and 5-HT3 receptor antagonists ketanserin and ICS 
      205-930 into the affected hind paw relieved mechanical hyperalgesia in a 
      dose-dependent fashion. These findings support the idea that in this rat model of 
      hyperalgesia due to peripheral nerve damage, NGF acts on mast cells to induce 
      release of 5-HT, which sensitizes nociceptors. Hyperalgesia due to nerve injury 
      and hyperalgesia due to inflammation may share some common features.
FAU - Theodosiou, M
AU  - Theodosiou M
AD  - School of Anatomy, University of New South Wales, Sydney NSW 2052, Australia 
      School of Physiology and Pharmacology, University of New South Wales, Sydney NSW 
      2052, Australia Department of Physiology, Flinders University, Adelaide SA 5001, 
      Australia.
FAU - Rush, A R
AU  - Rush AR
FAU - Zhou, F X
AU  - Zhou FX
FAU - Hu, D
AU  - Hu D
FAU - Walker, S J
AU  - Walker SJ
FAU - Tracey, J D
AU  - Tracey JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immune Sera)
RN  - 0 (Indoles)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Serotonin Antagonists)
RN  - 333DO1RDJY (Serotonin)
RN  - 6I819NIK1W (Tropisetron)
RN  - 97F9DE4CT4 (Ketanserin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/immunology/physiology
MH  - Disease Models, Animal
MH  - Humans
MH  - Hyperalgesia/*etiology/physiopathology/*therapy
MH  - Immune Sera/pharmacology
MH  - Immunization, Passive
MH  - Indoles/pharmacology/therapeutic use
MH  - Ketanserin/pharmacology/therapeutic use
MH  - Male
MH  - Mast Cells/drug effects
MH  - Nerve Growth Factors/immunology/*physiology
MH  - Neurotrophin 3
MH  - Nociceptors
MH  - Peripheral Nerves/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Sciatic Nerve/surgery
MH  - Serotonin/metabolism
MH  - Serotonin Antagonists/pharmacology/*therapeutic use
MH  - Tropisetron
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
AID - 00006396-199906010-00003 [pii]
AID - 10.1016/S0304-3959(99)00018-4 [doi]
PST - ppublish
SO  - Pain. 1999 Jun;81(3):245-255. doi: 10.1016/S0304-3959(99)00018-4.