PMID- 10432143
OWN - NLM
STAT- MEDLINE
DCOM- 19990830
LR  - 20190818
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 94
IP  - 2
DP  - 1999 Aug
TI  - Apoptosis in placentas from human T-lymphotropic virus type I-seropositive 
      pregnant women: a possible defense mechanism against transmission from mother to 
      fetus.
PG  - 279-83
AB  - OBJECTIVE: The mechanism by which the placenta serves as the barrier against 
      mother-to-fetus transmission of microorganisms remains to be elucidated. 
      Programmed cell death, apoptosis, is considered a cellular defense mechanism 
      against infection. The hypothesis of this study is that apoptosis of human 
      T-lymphotropic virus type I (HTLV-I)-infected placental villous cells is involved 
      in the defense mechanism against mother-to-fetus transmission of HTLV-I. METHODS: 
      Apoptosis was compared in term placentas from eight HTLV-I-seropositive pregnant 
      women and eight HTLV-I-seronegative pregnant women by the terminal 
      deoxynucleotidyl transferase-mediated deoxyuridine nick end-labeling method. In 
      addition, an in vitro cocultivation with an HTLV-I-infected lymphocyte cell line 
      (MT-2 cells) was performed to examine whether placental villous cells were 
      infected with HTLV-I and apoptosis was induced. RESULTS: The incidence of 
      apoptosis-positive cells (nuclei) in placentas from the HTLV-I-seropositive 
      pregnant women was higher than in the HTLV-I-seronegative pregnant women (P < 
      .02). Cocultivation with MT-2 cells showed that trophoblast cells were able to be 
      infected with HTLV-I and that apoptosis was induced in the placental villous 
      cells. CONCLUSION: HTLV-I infection induces apoptosis in the placenta. We 
      speculate that apoptosis may be involved in the defense mechanism of the placenta 
      against mother-to-fetus transmission of HTLV-I.
FAU - Fujino, T
AU  - Fujino T
AD  - School of Health Sciences, Kagoshima University, Japan. 
      toshinet@health.nop.kagoshima-u-ac-jp
FAU - Iwamoto, I
AU  - Iwamoto I
FAU - Otsuka, H
AU  - Otsuka H
FAU - Ikeda, T
AU  - Ikeda T
FAU - Takesako, S
AU  - Takesako S
FAU - Nagata, Y
AU  - Nagata Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Adult
MH  - *Apoptosis
MH  - Female
MH  - HTLV-I Infections/*transmission
MH  - Humans
MH  - *Infectious Disease Transmission, Vertical
MH  - Obstetric Labor, Premature/*pathology
MH  - Placenta/*pathology
MH  - Pregnancy
MH  - *Pregnancy Complications, Infectious
EDAT- 1999/08/04 00:00
MHDA- 1999/08/04 00:01
CRDT- 1999/08/04 00:00
PHST- 1999/08/04 00:00 [pubmed]
PHST- 1999/08/04 00:01 [medline]
PHST- 1999/08/04 00:00 [entrez]
AID - S0029-7844(99)00322-1 [pii]
AID - 10.1016/s0029-7844(99)00322-1 [doi]
PST - ppublish
SO  - Obstet Gynecol. 1999 Aug;94(2):279-83. doi: 10.1016/s0029-7844(99)00322-1.