PMID- 10432930
OWN - NLM
STAT- MEDLINE
DCOM- 19990818
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 112
IP  - 1
DP  - 1999 Jul 1
TI  - Loss of the Y-chromosome in the primary metastasis of a male sex cord stromal 
      tumor: pathogenetic implications.
PG  - 21-5
AB  - The first published chromosomal pattern of the retroperitoneal lymph node 
      metastasis of a malignant gonadal stroma cell tumor of the adult testis is 
      presented. Karyotyping showed structural chromosomal abnormalities and loss of 
      the Y-chromosome. This loss was confirmed in primary tumor and metastasis using 
      fluorescence in situ hybridization (FISH). The characteristic chromosomal 
      abnormality of adult testicular germ cell tumors, an i(12p), was not present. The 
      results are compared with other data of testicular and ovarian sex cord stromal 
      tumors. From the comparison of the male tumors, it is concluded that loss of the 
      Y-chromosome might have a pathogenetic significance.
FAU - de Graaff, W E
AU  - de Graaff WE
AD  - Department of Medical Oncology, University Hospital of Groningen, The 
      Netherlands.
FAU - van Echten, J
AU  - van Echten J
FAU - van der Veen, A Y
AU  - van der Veen AY
FAU - Sleijfer, D T
AU  - Sleijfer DT
FAU - Timmer, A
AU  - Timmer A
FAU - Schraffordt Koops, H
AU  - Schraffordt Koops H
FAU - de Jong, B
AU  - de Jong B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - *Chromosome Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Lymphatic Metastasis
MH  - Male
MH  - Metaphase
MH  - Middle Aged
MH  - Sex Cord-Gonadal Stromal Tumors/*genetics/pathology
MH  - *Y Chromosome
EDAT- 1999/08/05 00:00
MHDA- 1999/08/05 00:01
CRDT- 1999/08/05 00:00
PHST- 1999/08/05 00:00 [pubmed]
PHST- 1999/08/05 00:01 [medline]
PHST- 1999/08/05 00:00 [entrez]
AID - S0165460898002453 [pii]
AID - 10.1016/s0165-4608(98)00245-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jul 1;112(1):21-5. doi: 
      10.1016/s0165-4608(98)00245-3.