PMID- 10432937
OWN - NLM
STAT- MEDLINE
DCOM- 19990818
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 112
IP  - 1
DP  - 1999 Jul 1
TI  - Deletion of 6q27 in chronic lymphocytic leukemia and multiple myeloma detected by 
      fluorescence in situ hybridization.
PG  - 53-6
AB  - Nonrandom deletions of the long arm of chromosome 6 (6q) are associated with 
      various lymphoid malignancies. It has been suggested that deletions of 6q25-27, 
      6q21, and 6q23 typically occur in intermediate-grade, high-grade, and low-grade 
      lymphomas, respectively. We used fluorescence in situ hybridization (FISH) to 
      evaluate the occurrence of 6q27 deletion in chronic lymphatic leukemia (CLL) and 
      multiple myeloma (MM). 6q27 deletion was detected in 21% of patients with CLL and 
      in 28% of patients with MM. The percentage of cells containing deletions ranged 
      between 25-49. Two patients with MM had progressive disease and the aberration 
      was detected in both. We conclude that FISH is a sensitive method to detect 6q27 
      deletion in lymphoproliferative disorders. Also, this deletion is not specific to 
      intermediate-grade lymphomas, but occurs also in CLL and MM.
FAU - Amiel, A
AU  - Amiel A
AD  - Department of Medicine, Meir Hospital, Kfar-Saba, Israel.
FAU - Mulchanov, I
AU  - Mulchanov I
FAU - Elis, A
AU  - Elis A
FAU - Gaber, E
AU  - Gaber E
FAU - Manor, Y
AU  - Manor Y
FAU - Fejgin, M
AU  - Fejgin M
FAU - Lishner, M
AU  - Lishner M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 6
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology
EDAT- 1999/08/05 00:00
MHDA- 1999/08/05 00:01
CRDT- 1999/08/05 00:00
PHST- 1999/08/05 00:00 [pubmed]
PHST- 1999/08/05 00:01 [medline]
PHST- 1999/08/05 00:00 [entrez]
AID - S0165460898002556 [pii]
AID - 10.1016/s0165-4608(98)00255-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jul 1;112(1):53-6. doi: 
      10.1016/s0165-4608(98)00255-6.