PMID- 10433873
OWN - NLM
STAT- MEDLINE
DCOM- 19991008
LR  - 20150831
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 40
IP  - 2
DP  - 1999 Aug
TI  - Interleukin-3 or immunoglobulin E promotes expression of protein kinase C delta 
      gene in murine mast cells.
PG  - 147-51
AB  - We reported previously that protein kinase C delta (PKCdelta) is the main 
      isoenzyme in various types of murine mast cells. In the present study we 
      investigated the regulation of expression of PKCdelta gene in murine mast cells 
      in vitro and in vivo. The mRNA expressions of PKCdelta were promoted in response 
      to interleukin-3 (IL-3) or immunoglobulin E (IgE) in mouse mastocytoma P-815 
      cells. In addition we have evaluated the mast cells which express PKCdelta mRNA 
      in IgE-dependent passive cutaneous anaphylaxis reaction, using in situ 
      hybridization with the antisense riboprobe in skin. These results indicate that 
      mast cell activation can induce a marked promotion in steady state levels of 
      PKCdelta mRNA.
CI  - Copyright 1999 Academic Press.
FAU - Kim, H M
AU  - Kim HM
AD  - College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, South Korea.
FAU - Ko, S G
AU  - Ko SG
FAU - Kim, J J
AU  - Kim JJ
FAU - Chung, Y T
AU  - Chung YT
FAU - An, N H
AU  - An NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Dinitrophenols)
RN  - 0 (Interleukin-3)
RN  - 0 (Isoenzymes)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.1.- (Prkcd protein, mouse)
RN  - EC 2.7.1.- (Prkcd protein, rat)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.13 (Protein Kinase C-delta)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Dinitrophenols/immunology
MH  - Gene Expression/drug effects
MH  - Immunoglobulin E/immunology/*pharmacology
MH  - In Situ Hybridization
MH  - Interleukin-3/*pharmacology
MH  - Isoenzymes/*genetics
MH  - Male
MH  - Mast Cells/*drug effects/enzymology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Protein Kinase C/*genetics
MH  - Protein Kinase C-delta
MH  - RNA, Messenger/drug effects/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Cells, Cultured
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - S1043-6618(99)90471-1 [pii]
AID - 10.1006/phrs.1999.0471 [doi]
PST - ppublish
SO  - Pharmacol Res. 1999 Aug;40(2):147-51. doi: 10.1006/phrs.1999.0471.