PMID- 10435343
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190822
IS  - 0003-2654 (Print)
IS  - 0003-2654 (Linking)
VI  - 123
IP  - 12
DP  - 1998 Dec
TI  - Multi-residue analysis of penicillin residues in porcine tissue using matrix 
      solid phase dispersion.
PG  - 2779-83
AB  - The aim of this study was to develop a multi-residue method for the analysis of 
      penicillins in animal tissue. Matrix solid phase dispersion (MSPD) was employed 
      to extract the residues and the extracts were then cleaned-up by C18 solid phase 
      extraction (SPE). Pre-column derivatisation using acetic anhydride and 
      1,2,4-triazole in the presence of mercuric chloride was employed to allow 
      detection in 325 nm. Gradient elution was required to elute amoxicillin, 
      ampicillin, penicillin G, cloxacillin and dicloxacillin derivatives from a C18 
      reversed phase column using phosphate buffer-acetonitrile mobile phase. The 
      developed method had a limit of detection of 20 ng g-1 and had recoveries in the 
      range 40-90% for the 5 drugs in samples fortified at 40 and 200 ng g-1; the 
      maximum residue limits (MRLs) for these drugs were in the range of 50-300 ng g-1 
      (ppb).
FAU - McGrane, M
AU  - McGrane M
AD  - National Food Centre, Teagasc, Castleknock, Dublin, Ireland.
FAU - O'Keeffe, M
AU  - O'Keeffe M
FAU - Smyth, M R
AU  - Smyth MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Penicillins)
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Chromatography/methods
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - Humans
MH  - Meat/*analysis
MH  - Penicillins/*analysis/chemistry
MH  - Swine
MH  - Veterinary Drugs/*analysis/chemistry
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
AID - 10.1039/a805043k [doi]
PST - ppublish
SO  - Analyst. 1998 Dec;123(12):2779-83. doi: 10.1039/a805043k.