PMID- 10436057
OWN - NLM
STAT- MEDLINE
DCOM- 19990901
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 16
DP  - 1999 Aug 15
TI  - Long-term enhancement of central synaptic transmission by chronic brain-derived 
      neurotrophic factor treatment.
PG  - 7025-36
AB  - Acute effects of neurotrophins on synaptic plasticity have recently received much 
      attention, but the roles of these factors in regulating long-lasting changes in 
      synaptic function remain unclear. To address this issue we studied the long-term 
      (days to weeks) and short-term (minutes to hours) effects of brain-derived 
      neurotrophic factor (BDNF) on excitatory synaptic transmission in autaptic 
      cultures of hippocampal CA1 neurons. We found that BDNF induced long-term 
      enhancement of the strength of non-NMDA receptor-mediated glutamatergic 
      transmission. This upregulation of EPSC amplitude occurred via an increase in the 
      size of unitary synaptic currents, with no significant contribution from other 
      aspects of neuronal electrical and synaptic function including cell size, 
      voltage-gated sodium and potassium current levels, the number and size of 
      synaptic contacts, and the frequency of spontaneous neurotransmitter release. 
      Chronic BDNF treatment also decreased the degree of synaptic depression measured 
      in response to paired stimuli. Thus, BDNF induced long-term synaptic enhancement 
      of both basal and use-dependent synaptic transmission via specific changes to the 
      synapse rather than through generalized potentiation of neuronal growth and 
      differentiation. Finally, we showed that the long-term effects of BDNF are 
      functionally and mechanistically distinct from its acute effects on synaptic 
      transmission, suggesting that, in vivo, BDNF activation of Trk receptors can have 
      different functional effects depending on the time course of its action.
FAU - Sherwood, N T
AU  - Sherwood NT
AD  - Department of Neurobiology, Duke University Medical Center, Durham, North 
      Carolina 27710, USA.
FAU - Lo, D C
AU  - Lo DC
LA  - eng
GR  - 5F31MH11058/MH/NIMH NIH HHS/United States
GR  - NS32742/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cells, Cultured
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Neurons/drug effects
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptic Transmission/*drug effects
MH  - Time Factors
PMC - PMC6782869
EDAT- 1999/08/06 00:00
MHDA- 1999/08/06 00:01
PMCR- 2000/02/15
CRDT- 1999/08/06 00:00
PHST- 1999/08/06 00:00 [pubmed]
PHST- 1999/08/06 00:01 [medline]
PHST- 1999/08/06 00:00 [entrez]
PHST- 2000/02/15 00:00 [pmc-release]
AID - 3299 [pii]
AID - 10.1523/JNEUROSCI.19-16-07025.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Aug 15;19(16):7025-36. doi: 10.1523/JNEUROSCI.19-16-07025.1999.