PMID- 10438355
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20220311
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 180
IP  - 3
DP  - 1999 Sep
TI  - HTLV-I/II seroindeterminate Western blot reactivity in a cohort of patients with 
      neurological disease.
PG  - 685-94
AB  - The human T-cell lymphotropic virus type I (HTLV-I) is associated with a chronic, 
      progressive neurological disease known as HTLV-I-associated myelopathy/tropical 
      spastic paraparesis. Screening for HTLV-I involves the detection of 
      virus-specific serum antibodies by EIA and confirmation by Western blot. 
      HTLV-I/II seroindeterminate Western blot patterns have been described worldwide. 
      However, the significance of this blot pattern is unclear. We identified 8 
      patients with neurological disease and an HTLV-I/II seroindeterminate Western 
      blot pattern, none of whom demonstrated increased spontaneous proliferation and 
      HTLV-I-specific cytotoxic T lymphocyte activity. However, HTLV-I tax sequence was 
      amplified from the peripheral blood lymphocytes of 4 of them. These data suggest 
      that patients with chronic progressive neurological disease and HTLV-I/II Western 
      blot seroindeterminate reactivity may harbor either defective HTLV-I, novel 
      retrovirus with partial homology to HTLV-I, or HTLV-I in low copy number.
FAU - Soldan, S S
AU  - Soldan SS
AD  - Viral Immunology Section, National Institute of Neurological Disorders and 
      Stroke, Bethesda, Maryland 20892, USA.
FAU - Graf, M D
AU  - Graf MD
FAU - Waziri, A
AU  - Waziri A
FAU - Flerlage, A N
AU  - Flerlage AN
FAU - Robinson, S M
AU  - Robinson SM
FAU - Kawanishi, T
AU  - Kawanishi T
FAU - Leist, T P
AU  - Leist TP
FAU - Lehky, T J
AU  - Lehky TJ
FAU - Levin, M C
AU  - Levin MC
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (HTLV-II Antibodies)
SB  - IM
MH  - Adult
MH  - Blotting, Western/methods
MH  - Cohort Studies
MH  - Female
MH  - Genes, Viral
MH  - HTLV-I Antibodies/blood
MH  - HTLV-II Antibodies/blood
MH  - HTLV-II Infections/immunology/physiopathology/*virology
MH  - Human T-lymphotropic virus 1/*isolation & purification
MH  - Human T-lymphotropic virus 2/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/immunology/*virology
MH  - Paraparesis, Tropical Spastic/immunology/physiopathology/*virology
MH  - Polymerase Chain Reaction
EDAT- 1999/08/07 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/08/07 10:00
PHST- 1999/08/07 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/08/07 10:00 [entrez]
AID - JID981241 [pii]
AID - 10.1086/314923 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Sep;180(3):685-94. doi: 10.1086/314923.