PMID- 10438385
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20220228
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 180
IP  - 3
DP  - 1999 Sep
TI  - Polymorphism of the 5'-flanking region of the tumor necrosis factor (TNF)-alpha 
      gene and susceptibility to human T-cell lymphotropic virus type I (HTLV-I) 
      uveitis.
PG  - 880-3
AB  - The genetic background of human T-cell lymphotropic virus type I (HTLV-I) uveitis 
      (HU) was investigated by studying the distribution of 5 polymorphisms of the 
      5'-flanking promoter/enhancer region of the tumor necrosis factor (TNF)-alpha 
      gene in patients with HU, together with patients with adult T-cell leukemia 
      (ATL), asymptomatic HTLV-I carriers, and healthy controls. The frequencies of the 
      -1,031C allele (T-->C transition at position -1,031) and -863A allele (C-->A 
      transition at position -863) in the HU patients, but neither in the ATL patients 
      nor in the carriers, were significantly higher than those in the controls. The 
      -1,031C and -863A alleles, in the absence of the HLA B61 or the DRB1*0901 allele 
      which is in linkage disequilibrium with these alleles, were associated with 
      increased susceptibility to HU. These results suggest that the -1,031C and -863A 
      alleles might be genetic risk factors for HU.
FAU - Seki, N
AU  - Seki N
AD  - Department of Immunology, Kurume University School of Medicine, Kurume, Japan.
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Yamada, A
AU  - Yamada A
FAU - Kamizono, S
AU  - Kamizono S
FAU - Sugita, S
AU  - Sugita S
FAU - Taguchi, C
AU  - Taguchi C
FAU - Matsuoka, M
AU  - Matsuoka M
FAU - Matsumoto, H
AU  - Matsumoto H
FAU - Nishizaka, S
AU  - Nishizaka S
FAU - Itoh, K
AU  - Itoh K
FAU - Mochizuki, M
AU  - Mochizuki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Carrier State/immunology
MH  - Genetic Predisposition to Disease/immunology
MH  - Genetic Variation
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - HTLV-I Infections/*genetics/immunology
MH  - Humans
MH  - Japan
MH  - *Polymorphism, Genetic
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Uveitis/genetics/immunology/*virology
EDAT- 1999/08/07 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/08/07 10:00
PHST- 1999/08/07 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/08/07 10:00 [entrez]
AID - JID980954 [pii]
AID - 10.1086/314917 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Sep;180(3):880-3. doi: 10.1086/314917.