PMID- 10439445
OWN - NLM
STAT- MEDLINE
DCOM- 19990930
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 11
DP  - 1999 Aug 2
TI  - Short-term potentiation of carotid chemoreflex: an NMDAR-dependent neural 
      integrator.
PG  - 2261-5
AB  - Repetitive stimulation of the carotid sinus nerve (CSN) elicits a short-term 
      potentiation (STP) of the reflex response in respiratory motor output in mammals. 
      The input-output transformation approximates a leaky integrator with a time 
      constant of several seconds. Here, we showed that STP induced by CSN stimulation 
      in rats was manifested in the reflex response in the amplitude of rhythmic 
      phrenic nerve activity as well as its duration. Moreover, pharmacological 
      blockade of NMDA receptors (NMDAR) resulted in marked increases in the time 
      constants of the equivalent neural integrator in both the STP induction phase (by 
      10- to 20-fold) and recovery phase (by 1- to 5-fold). Thus, NMDAR serves as a 
      molecular switch that facilitates the integrative processing of CSN inputs by 
      STP.
FAU - Poon, C S
AU  - Poon CS
AD  - Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute 
      of Technology, Cambridge 02139, USA.
FAU - Siniaia, M S
AU  - Siniaia MS
FAU - Young, D L
AU  - Young DL
FAU - Eldridge, F L
AU  - Eldridge FL
LA  - eng
GR  - HL52925/HL/NHLBI NIH HHS/United States
GR  - HL60064/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Carotid Sinus/*innervation
MH  - Chemoreceptor Cells/*physiology
MH  - Electric Stimulation/methods
MH  - Male
MH  - Models, Neurological
MH  - Periodicity
MH  - Phrenic Nerve/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Reflex/*physiology
MH  - Respiratory Physiological Phenomena
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1097/00001756-199908020-00007 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Aug 2;10(11):2261-5. doi: 10.1097/00001756-199908020-00007.