PMID- 10440532
OWN - NLM
STAT- MEDLINE
DCOM- 19991028
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 80
IP  - 2
DP  - 1999 Jun
TI  - Pharmacological characterization of capsaicin-induced body movement of neonatal 
      rat.
PG  - 137-42
AB  - In neonatal rats, nociceptive responses induced by capsaicin were characterized 
      pharmacologically. Capsaicin, injected subcutaneously (s.c.), induced body 
      movement including scratching and struggling responses, and the responses were 
      quantified by using a device composed of an audio speaker as a detector. The 
      capsaicin-induced body movement was inhibited by a tachykinin NK1-receptor 
      antagonist RP-67580 with an ID50 value of 3.5 mg/kg, s.c. Opioid analgesics, 
      morphine, buprenorphine and pentazocine, also inhibited the body movement with 
      ID50 values of 0.085, 0.0079 and 0.92 (mg/kg, s.c.), respectively. Non-steroidal 
      anti-inflammatory drugs, indomethacin, ibuprofen and acetaminophen, did not exert 
      any effect on the capsaicin-induced body movement. Neither the sedative diazepam 
      nor the sedative chlorpromazine inhibited the body movement. It is concluded that 
      the capsaicin-induced body movement in neonatal rats, which is considered to be 
      nociceptive responses mediated by substance P, is sensitive to centrally acting 
      analgesics with micro-opioid receptor agonist activity.
FAU - Kubota, K
AU  - Kubota K
AD  - Biological Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
FAU - Kubota-Watanabe, M
AU  - Kubota-Watanabe M
FAU - Fujibayashi, K
AU  - Fujibayashi K
FAU - Saito, K
AU  - Saito K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Opioid Peptides)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Capsaicin/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hypnotics and Sedatives/pharmacology
MH  - Movement/*drug effects
MH  - Opioid Peptides/pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1254/jjp.80.137 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1999 Jun;80(2):137-42. doi: 10.1254/jjp.80.137.