PMID- 10441003
OWN - NLM
STAT- MEDLINE
DCOM- 19990827
LR  - 20220408
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 26
IP  - 1
DP  - 1999 Sep
TI  - Sporadic follicular thyroid tumors show loss of a 200-kb region in 11q13 without 
      evidence for mutations in the MEN1 gene.
PG  - 35-9
AB  - Loss of heterozygosity (LOH) in 11q13 where the tumor suppressor gene for 
      multiple endocrine neoplasia type 1 (MEN 1) is located has been demonstrated in 
      several tumor types, including follicular thyroid tumors, but whether the MEN1 
      gene is actually involved in their tumorigenesis is not known. In the present 
      study, the involvement of the MEN1 gene in follicular thyroid tumors was 
      investigated. By using 14 MEN1-linked microsatellite markers, LOH was 
      demonstrated in 12 out of 60 follicular thyroid tumors: 2/18 adenomas, 4/15 
      atypical adenomas, 1/6 Hurthle cell adenomas, 1/9 carcinomas, 3/6 Hurthle cell 
      carcinomas, and 1/6 anaplastic carcinomas. In the tumors with LOH, a single 
      minimal region of overlapping deletions was mapped to the 200-kb interval between 
      D11S4946 and D11S4939. Tumors that showed 11q13 LOH were screened for mutations 
      of the MEN1 gene using single-strand conformation analysis. Abnormal shifts 
      detected in seven tumors in two exons were sequenced, which revealed two 
      different polymorphisms present in both tumor and constitutional DNA, but without 
      somatic mutation. Taken together, these results suggest that in this region, a 
      tumor suppressor gene other than MEN1 might be involved in the tumorigenesis of 
      follicular thyroid tumors. Genes Chromosomes Cancer 26:35-39, 1999.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Nord, B
AU  - Nord B
AD  - Endocrine Tumor Unit, Department of Molecular Medicine, Karolinska Hospital, 
      Stockholm, Sweden.
FAU - Larsson, C
AU  - Larsson C
FAU - Wong, F K
AU  - Wong FK
FAU - Wallin, G
AU  - Wallin G
FAU - Teh, B T
AU  - Teh BT
FAU - Zedenius, J
AU  - Zedenius J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenocarcinoma, Follicular/*genetics
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/chemistry/genetics
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Microsatellite Repeats
MH  - Mutation
MH  - Neoplasm Proteins/*genetics
MH  - Polymorphism, Single-Stranded Conformational
MH  - *Proto-Oncogene Proteins
MH  - Thyroid Neoplasms/*genetics
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199909)26:1<35::AID-GCC5>3.0.CO;2-L [pii]
AID - 10.1002/(sici)1098-2264(199909)26:1<35::aid-gcc5>3.0.co;2-l [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Sep;26(1):35-9. doi: 
      10.1002/(sici)1098-2264(199909)26:1<35::aid-gcc5>3.0.co;2-l.