PMID- 10441007
OWN - NLM
STAT- MEDLINE
DCOM- 19990827
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 26
IP  - 1
DP  - 1999 Sep
TI  - Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.
PG  - 62-9
AB  - We studied the involvement of PRIM1 in osteosarcoma by differential display, 
      Northern and Southern hybridization, as well as fluorescence in situ 
      hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology 
      specimens were tested. PRIM1 was found to be amplified in 41% of the samples. 
      PRIM1 is coamplified with the core 12q13 amplicon genes CDK4, SAS, and OS9, and 
      was physically mapped very close to them. PRIM1 is therefore a new candidate for 
      the role of a major target gene of 12q13 amplifications in human cancers. Genes 
      Chromosomes Cancer 26:62-69, 1999.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Yotov, W V
AU  - Yotov WV
AD  - Departement de Pediatrie, Hopital Ste-Justine, Universite de Montreal, Montreal, 
      Quebec, Canada. yotovw@ere.umontreal.ca
FAU - Hamel, H
AU  - Hamel H
FAU - Rivard, G E
AU  - Rivard GE
FAU - Champagne, M A
AU  - Champagne MA
FAU - Russo, P A
AU  - Russo PA
FAU - Leclerc, J M
AU  - Leclerc JM
FAU - Bernstein, M L
AU  - Bernstein ML
FAU - Levy, E
AU  - Levy E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Lectins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (OS9 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (TSPAN31 protein, human)
RN  - 0 (Tetraspanins)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
RN  - EC 2.7.7.- (DNA Primase)
SB  - IM
MH  - Blotting, Northern
MH  - Bone Neoplasms/enzymology/*genetics
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Cyclin-Dependent Kinase 4
MH  - Cyclin-Dependent Kinases/genetics
MH  - DNA Primase/*genetics
MH  - DNA, Neoplasm/genetics
MH  - Gene Amplification
MH  - Gene Expression Regulation, Neoplastic
MH  - HeLa Cells
MH  - Humans
MH  - Hybrid Cells
MH  - In Situ Hybridization, Fluorescence
MH  - Lectins
MH  - Membrane Proteins/genetics
MH  - Neoplasm Proteins/genetics
MH  - Osteosarcoma/enzymology/*genetics
MH  - Physical Chromosome Mapping
MH  - *Proto-Oncogene Proteins
MH  - RNA, Messenger/genetics
MH  - Tetraspanins
MH  - Tumor Cells, Cultured
EDAT- 1999/08/10 00:00
MHDA- 1999/08/10 00:01
CRDT- 1999/08/10 00:00
PHST- 1999/08/10 00:00 [pubmed]
PHST- 1999/08/10 00:01 [medline]
PHST- 1999/08/10 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199909)26:1<62::AID-GCC9>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Sep;26(1):62-9. doi: 
      10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f.