PMID- 10441168
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20061115
IS  - 0896-8411 (Print)
IS  - 0896-8411 (Linking)
VI  - 13
IP  - 1
DP  - 1999 Aug
TI  - The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine 
      atherosclerosis.
PG  - 57-60
AB  - Atherosclerosis is a multifactorial process, the hallmark of which is fat 
      deposition in the vessel wall. Autoimmune factors have recently been shown to 
      play an important role in the initiation and progression of atherosclerosis; 
      candidate autoantigens are oxidized lipids and heat shock proteins. 
      beta2-glycoprotein I (beta2-GPI) is a highly glycosylated plasma protein that 
      serves as a major antigenic target for autoimmune type antiphospholipid 
      antibodies. Its major relevant property is binding to negatively charged 
      phospholipids/surfaces. In the set of studies presented in this paper, we provide 
      evidence pointing towards beta2-GPI as an influential determinant in murine and 
      human atherogenesis. Thus, immunization of transgenic atherosclerosis-prone mice 
      (apolipoprotein E and low-density lipoprotein receptor knockouts) with human 
      beta2-GPI results in a brisk and sustained respective response that extends to 
      cross-react with the 'self' murine beta2-GPI. Atherosclerosis is accelerated in 
      both strains concomitant with the infiltration of CD4 lymphocytes in the aortic 
      sinus of the mice. When human plaques were studied, it was found that beta2-GPI 
      resides in the subendothelial regions and co-localizes with CD4 lymphocytes. 
      Thus, the immune response towards beta2-GPI may play an important role in 
      atherogenesis, serving as a possible target for antigen specific therapies.
CI  - Copyright 1999 Academic Press.
FAU - George, J
AU  - George J
AD  - Department of Medicine 'B' and the Research Unit of Autoimmune Diseases, Sheba 
      Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, 
      Tel-Aviv, Israel.
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
FAU - Harats, D
AU  - Harats D
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Autoimmun
JT  - Journal of autoimmunity
JID - 8812164
RN  - 0 (Apolipoproteins E)
RN  - 0 (Autoantigens)
RN  - 0 (Glycoproteins)
RN  - 0 (Receptors, LDL)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/deficiency/genetics
MH  - Arteriosclerosis/blood/*etiology/*immunology
MH  - Autoantigens
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cross Reactions
MH  - Disease Models, Animal
MH  - Endothelium/metabolism
MH  - Glycoproteins/blood/*immunology
MH  - Humans
MH  - Immunization
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, LDL/deficiency/genetics
MH  - U937 Cells
MH  - beta 2-Glycoprotein I
EDAT- 1999/08/11 00:00
MHDA- 1999/08/11 00:01
CRDT- 1999/08/11 00:00
PHST- 1999/08/11 00:00 [pubmed]
PHST- 1999/08/11 00:01 [medline]
PHST- 1999/08/11 00:00 [entrez]
AID - S0896-8411(99)90288-3 [pii]
AID - 10.1006/jaut.1999.0288 [doi]
PST - ppublish
SO  - J Autoimmun. 1999 Aug;13(1):57-60. doi: 10.1006/jaut.1999.0288.