PMID- 10441626 OWN - NLM STAT- MEDLINE DCOM- 19990902 LR - 20191103 IS - 1093-5266 (Print) IS - 1093-5266 (Linking) VI - 2 IP - 5 DP - 1999 Sep-Oct TI - Consistency of isochromosome 7q and trisomy 8 in hepatosplenic gammadelta T-cell lymphoma: detection by fluorescence In situ hybridization of a splenic touch-preparation from a pediatric patient. PG - 478-83 AB - Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen. FAU - Coventry, S AU - Coventry S AD - Department of Pathology, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134, USA. FAU - Punnett, H H AU - Punnett HH FAU - Tomczak, E Z AU - Tomczak EZ FAU - Casher, D AU - Casher D FAU - Koehler, M AU - Koehler M FAU - Borowitz, M J AU - Borowitz MJ FAU - Griffin, C A AU - Griffin CA FAU - de Chadarevian, J P AU - de Chadarevian JP LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Pediatr Dev Pathol JT - Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society JID - 9809673 RN - 0 (Receptors, Antigen, T-Cell, gamma-delta) SB - IM MH - Child MH - *Chromosomes, Human, Pair 7/*genetics MH - Chromosomes, Human, Pair 8/*genetics MH - Flow Cytometry MH - Humans MH - In Situ Hybridization, Fluorescence MH - Isochromosomes/*genetics MH - Liver Neoplasms/*genetics/pathology MH - Lymphoma, T-Cell/*genetics/pathology MH - Male MH - Receptors, Antigen, T-Cell, gamma-delta/genetics MH - Splenic Neoplasms/*genetics/pathology MH - Trisomy/*genetics EDAT- 1999/08/12 00:00 MHDA- 1999/08/12 00:01 CRDT- 1999/08/12 00:00 PHST- 1999/08/12 00:00 [pubmed] PHST- 1999/08/12 00:01 [medline] PHST- 1999/08/12 00:00 [entrez] AID - 98-91R [pii] AID - 10.1007/s100249900152 [doi] PST - ppublish SO - Pediatr Dev Pathol. 1999 Sep-Oct;2(5):478-83. doi: 10.1007/s100249900152.