PMID- 10442521
OWN - NLM
STAT- MEDLINE
DCOM- 19991021
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 54
IP  - 7
DP  - 1999 Jul
TI  - The role of immunoglobulin therapy in allergic diseases.
PG  - 662-8
AB  - Intravenous immunoglobulin (IVIG) has been used for many years to treat patients 
      with primary immunodeficiencies. More recently, IVIG has been shown to have 
      anti-inflammatory activity when used at substantially higher concentrations. A 
      number of studies have examined the efficacy of IVIG in allergic diseases. For 
      patients with severe refractory asthma, sinusitis, atopic dermatitis, and 
      urticaria, IVIG offers an alternative therapy with relatively few side-effects. 
      Although the mechanism by which IVIG may attenuate the allergic response is still 
      undetermined, clinical studies have shown that immunoglobulin therapy can 
      decrease serum IgE levels and increase glucocorticoid binding affinity, while in 
      vitro studies have shown that IVIG can decrease T-cell secretion of TH2 
      cytokines. Further studies are needed to confirm the initial encouraging results 
      seen in allergic patients with severe, resistant disease.
FAU - Rabinovitch, N
AU  - Rabinovitch N
AD  - Department of Pediatrics, National Jewish Medical and Research Center, Denver, 
      CO, USA.
FAU - Gelfand, E W
AU  - Gelfand EW
FAU - Leung, D Y
AU  - Leung DY
LA  - eng
GR  - AR41256/AR/NIAMS NIH HHS/United States
GR  - HL36577/HL/NHLBI NIH HHS/United States
GR  - HL37260/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adult
MH  - Child
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Hypersensitivity, Immediate/*therapy
MH  - *Immunization, Passive
MH  - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use
RF  - 28
EDAT- 1999/08/12 00:00
MHDA- 1999/08/12 00:01
CRDT- 1999/08/12 00:00
PHST- 1999/08/12 00:00 [pubmed]
PHST- 1999/08/12 00:01 [medline]
PHST- 1999/08/12 00:00 [entrez]
AID - 10.1034/j.1398-9995.1999.00094.x [doi]
PST - ppublish
SO  - Allergy. 1999 Jul;54(7):662-8. doi: 10.1034/j.1398-9995.1999.00094.x.