PMID- 10443665
OWN - NLM
STAT- MEDLINE
DCOM- 19990819
LR  - 20070417
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 84
IP  - 8
DP  - 1999 Aug
TI  - Plasma chromogranin A in patients with multiple endocrine neoplasia type 1.
PG  - 2712-7
AB  - Plasma chromogranin A (CgA) has been claimed to be a sensitive marker for 
      neuroendocrine tumors, but its role in the early diagnosis of multiple endocrine 
      neoplasia type 1 (MEN 1) pancreatic endocrine tumors has not been evaluated. We 
      measured CgA in 36 patients with MEN 1, of whom 9 lacked pancreatic involvement, 
      20 had biochemical evidence of pancreatic endocrine tumors, and 7 displayed 
      radiologically detectable pancreatic tumors. CgA was also analyzed in 25 patients 
      with sporadic pancreatic endocrine tumors, 39 subjects with inflammatory bowel 
      disease, 7 patients harboring nonendocrine pancreatic disease, and 19 healthy 
      controls. Four of 9 of the MEN 1 patients without pancreatic involvement had 
      elevated CgA. Furthermore, 60% with biochemically unequivocal tumors and all with 
      a radiologically visible tumor showed elevations. All 25 patients with sporadic 
      pancreatic endocrine tumor had increased CgA, as had 28% of patients with 
      inflammatory bowel disease and 57% with nonendocrine pancreatic disease. Mean day 
      to day CgA variation was 29% (range, 0-113%) in the neuroendocrine tumor patients 
      and 21.0% (range, 0.0-47%, within reference range) among healthy controls. In 
      summary, nonendocrine diseases may cause elevation of CgA, and its spontaneous 
      variation can be considerable. Plasma chromogranin A is the most sensitive of the 
      basal markers for neuroendocrine tumors, but cannot replace other established 
      measures when screening for early pancreatic involvement in MEN 1.
FAU - Granberg, D
AU  - Granberg D
AD  - Department of Medical Sciences, University Hospital, Uppsala, Sweden.
FAU - Stridsberg, M
AU  - Stridsberg M
FAU - Seensalu, R
AU  - Seensalu R
FAU - Eriksson, B
AU  - Eriksson B
FAU - Lundqvist, G
AU  - Lundqvist G
FAU - Oberg, K
AU  - Oberg K
FAU - Skogseid, B
AU  - Skogseid B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (CHGA protein, human)
RN  - 0 (Chromogranin A)
RN  - 0 (Chromogranins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromogranin A
MH  - Chromogranins/*blood
MH  - Female
MH  - Humans
MH  - Inflammatory Bowel Diseases/blood
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*blood
MH  - Pancreatic Neoplasms/*blood
MH  - Pancreatitis/blood
EDAT- 1999/08/12 00:00
MHDA- 1999/08/12 00:01
CRDT- 1999/08/12 00:00
PHST- 1999/08/12 00:00 [pubmed]
PHST- 1999/08/12 00:01 [medline]
PHST- 1999/08/12 00:00 [entrez]
AID - 10.1210/jcem.84.8.5938 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1999 Aug;84(8):2712-7. doi: 10.1210/jcem.84.8.5938.