PMID- 10443911
OWN - NLM
STAT- MEDLINE
DCOM- 19990913
LR  - 20131121
IS  - 0954-691X (Print)
IS  - 0954-691X (Linking)
VI  - 11 Suppl 1
DP  - 1999 Jun
TI  - My approach to Helicobacter pylori eradication.
PG  - S37-41
AB  - The eradication of Helicobacter pylori is advantageous in many diseases of the 
      upper gastrointestinal tract and can result in the cure of conditions such as 
      peptic ulcer disease. It may also potentially prevent the development of gastric 
      cancer. Complete eradication of H. pylori can be difficult to achieve, and the 
      effectiveness of many combinations of agents has been tested in clinical trials 
      over the years. No agent has been found to be effective at eradicating H. pylori 
      when given alone and this has resulted in the development of combination 
      therapies comprising an antisecretory agent and one or more antibiotics. 
      Bismuth-based triple therapies, while considered for years as the 'gold 
      standard', have limited efficacy and may be associated with significant side 
      effects. Dual therapies, comprising a proton pump inhibitor (PPI) and one 
      antibiotic, marked a milestone in the history of H. pylori eradication therapy 
      but have shown inconsistent results and eradication rates of less than 60%. 
      However, these have provided the basis for the development of short-term, 
      low-dose PPI triple therapies, including two antibiotics from among 
      metronidazole, clarithromycin and amoxycillin plus a PPI that have demonstrated 
      excellent eradication rates approaching 100%.
FAU - Bazzoli, F
AU  - Bazzoli F
AD  - Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di 
      Bologna, Italy.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Penicillins)
RN  - 0 (Proton Pump Inhibitors)
RN  - 140QMO216E (Metronidazole)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Amoxicillin/administration & dosage
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Clarithromycin/administration & dosage
MH  - Helicobacter Infections/*drug therapy
MH  - *Helicobacter pylori
MH  - Humans
MH  - Metronidazole/administration & dosage
MH  - Penicillins/administration & dosage
MH  - Proton Pump Inhibitors
EDAT- 1999/08/12 00:00
MHDA- 1999/08/12 00:01
CRDT- 1999/08/12 00:00
PHST- 1999/08/12 00:00 [pubmed]
PHST- 1999/08/12 00:01 [medline]
PHST- 1999/08/12 00:00 [entrez]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 1999 Jun;11 Suppl 1:S37-41.