PMID- 10444538
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20230411
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 277
IP  - 2
DP  - 1999 Aug
TI  - Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus 
      fat.
PG  - R337-45
LID - 10.1152/ajpregu.1999.277.2.R337 [doi]
AB  - We assessed the extent to which a possible synchronization between transient 
      blood glucose declines and spontaneous meal initiation would lend support to the 
      interpretation of a preload study with isoenergetic (1 MJ) isovolumetric high-fat 
      or simple carbohydrate (CHO) preload drinks. Ten men (18-30 yr) fasted overnight 
      and then were time blinded and made aware that they could request meals anytime. 
      At first meal requests, volunteers consumed a preload; ad libitum meals were 
      offered at subsequent requests. Postabsorptively, transient declines in blood 
      glucose were associated with meal requests (chi(2) = 8.29). Subsequent meal 
      requests occurred during "dynamic declines" in blood glucose after the peak 
      induced by drink consumption (100%). These meal requests took twice as long to 
      occur after high-fat than after CHO preloads (fat = 126 +/- 21, CHO = 65 +/- 15 
      min), consistent with differences in interpolated 65-min satiety scores (fat = 38 
      +/- 8.2, CHO = 16 +/- 4). Postprandially, transient blood glucose declines were 
      associated with meal requests (chi(2) = 4.30). Spontaneous meal initiations were 
      synchronized with transient and dynamic blood glucose declines. Synchronization 
      of intermeal interval and dynamic declines related to higher satiating efficiency 
      from high-fat preloads than from simple CHO preloads.
FAU - Melanson, K J
AU  - Melanson KJ
AD  - Department of Human Biology, Maastricht University, 6200 MD Maastricht, The 
      Netherlands.
FAU - Westerterp-Plantenga, M S
AU  - Westerterp-Plantenga MS
FAU - Saris, W H
AU  - Saris WH
FAU - Smith, F J
AU  - Smith FJ
FAU - Campfield, L A
AU  - Campfield LA
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - Appetite/drug effects/*physiology
MH  - Blood Glucose/*analysis/drug effects
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Drinking/physiology
MH  - Feeding Behavior/physiology
MH  - Humans
MH  - Hunger/physiology
MH  - Male
MH  - Satiety Response/physiology
MH  - *Time Perception
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
AID - 10.1152/ajpregu.1999.277.2.R337 [doi]
PST - ppublish
SO  - Am J Physiol. 1999 Aug;277(2):R337-45. doi: 10.1152/ajpregu.1999.277.2.R337.