PMID- 10444618
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 87
IP  - 2
DP  - 1999 Aug
TI  - Role of submaximal exercise in promoting creatine and glycogen accumulation in 
      human skeletal muscle.
PG  - 598-604
AB  - We examined the effect of glycogen-depleting exercise on subsequent muscle total 
      creatine (TCr) accumulation and glycogen resynthesis during postexercise periods 
      when the diet was supplemented with carbohydrate (CHO) or creatine (Cr) + CHO. 
      Fourteen subjects performed one-legged cycling exercise to exhaustion. Muscle 
      biopsies were taken from the exhausted (Ex) and nonexhausted (Nex) limbs after 
      exercise and after 6 h and 5 days of recovery, during which CHO (CHO group, n = 
      7) or Cr + CHO (Cr+CHO group, n = 7) supplements were ingested. Muscle TCr 
      concentration ([TCr]) was unchanged in both groups 6 h after supplementation 
      commenced but had increased in the Ex (P < 0.001) and Nex limbs (P < 0.05) of the 
      Cr+CHO group after 5 days. Greater TCr accumulation was achieved in the Ex limbs 
      (P < 0.01) of this group. Glycogen was increased above nonexercised 
      concentrations in the Ex limbs of both groups after 5 days, with the 
      concentration being greater in the Cr+CHO group (P = 0.06). Thus a single bout of 
      exercise enhanced muscle Cr accumulation, and this effect was restricted to the 
      exercised muscle. However, exercise also diminished CHO-mediated insulin release, 
      which may have attenuated insulin-mediated muscle Cr accumulation. Ingesting Cr 
      with CHO also augmented glycogen supercompensation in the exercised muscle.
FAU - Robinson, T M
AU  - Robinson TM
AD  - School of Biomedical Sciences, University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham NG7 2UH, United Kingdom.
FAU - Sewell, D A
AU  - Sewell DA
FAU - Hultman, E
AU  - Hultman E
FAU - Greenhaff, P L
AU  - Greenhaff PL
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - 9005-79-2 (Glycogen)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adenosine Triphosphate/analysis
MH  - Adult
MH  - Blood Glucose
MH  - Creatine/*metabolism
MH  - Diet
MH  - Dietary Supplements
MH  - Exercise/*physiology
MH  - Female
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - Phosphocreatine/analysis
MH  - Time Factors
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
AID - 10.1152/jappl.1999.87.2.598 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1999 Aug;87(2):598-604. doi: 10.1152/jappl.1999.87.2.598.