PMID- 10445072
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20190905
IS  - 0365-5237 (Print)
IS  - 0365-5237 (Linking)
VI  - 540
DP  - 1999
TI  - 4-methylcatechol, a potent inducer of nerve growth factor synthesis, protects 
      spiral ganglion neurons from aminoglycoside ototoxicity--preliminary report.
PG  - 12-5
AB  - The degeneration of spiral ganglion neurons after hair cell destruction following 
      aminoglycoside ototoxicity is associated not only with the direct effect on the 
      neurons, but also with a loss of neurotrophic factors provided by auditory hair 
      cells. The neurotrophic factors, including nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been 
      reported to be effective in enhancing neuronal survival against aminoglycoside 
      ototoxicity in vivo. To determine whether 4-methylcatechol (4-MC), a potent 
      inducer of nerve growth factor synthesis, can protect spiral ganglion neurons 
      after aminoglycoside treatment in vivo, we studied the spiral ganglion neurons of 
      gentamicin (GM)-treated mice with or without 4-MC administration. We found that 
      the number of surviving spiral ganglion neurons of 4-MC-treated animals was 
      significantly greater than for those treated with GM alone. Our results suggest 
      that 4-MC promotes synthesis of NGF (and/or other neurotrophins), which enhances 
      spiral ganglion neuron survival after gentamicin treatment.
FAU - Kimura, N
AU  - Kimura N
AD  - Department of Otorhinolaryngology, Okayama University Medical School, Japan. 
      me4606@hp.okayama-u.ac.jp
FAU - Nishizaki, K
AU  - Nishizaki K
FAU - Orita, Y
AU  - Orita Y
FAU - Masuda, Y
AU  - Masuda Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Otolaryngol Suppl
JT  - Acta oto-laryngologica. Supplementum
JID - 0370355
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catechols)
RN  - 0 (Gentamicins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 12GLI7JGB3 (4-methylcatechol)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*toxicity
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Catechols/*pharmacology
MH  - Female
MH  - Gentamicins/*toxicity
MH  - Male
MH  - Mice
MH  - Nerve Growth Factors/biosynthesis
MH  - Neurons/drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Spiral Ganglion/cytology/*drug effects
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
AID - 10.1080/00016489950181125 [doi]
PST - ppublish
SO  - Acta Otolaryngol Suppl. 1999;540:12-5. doi: 10.1080/00016489950181125.