PMID- 10445073
OWN - NLM
STAT- MEDLINE
DCOM- 19990923
LR  - 20131121
IS  - 0365-5237 (Print)
IS  - 0365-5237 (Linking)
VI  - 540
DP  - 1999
TI  - Calbindin and calmodulin localization in the developing vestibular organ of the 
      musk shrew (Suncus murinus).
PG  - 16-21
AB  - The distribution of the Ca(2+)-binding proteins, calbindin and calmodulin, in the 
      adult inner ear has been described previously. We undertook immunohistochemical 
      investigation of developmental changes in the distribution of calbindin and 
      calmodulin in the vestibular organ of the musk shrew (Suncus murinus). Expression 
      of calbindin was seen first in the hair cells and the vestibular ganglion on 
      gestational day (GD) 19, in nerve fibres on GD23 and in the otoconia on GD26. On 
      GD19 calmodulin was demonstrable only in the hair cells. On GD26 both 
      Ca(2+)-binding proteins showed a distribution of immunoreactivity in hair cells 
      similar to that seen in adults. The developmental differences in distribution of 
      these binding proteins may suggest different roles in the vestibule. 
      Additionally, Ca(2+)-binding proteins may be a useful index of hair cell 
      maturity.
FAU - Karita, K
AU  - Karita K
AD  - Department of Otorhinolaryngology, Okayama University Medical School, Japan.
FAU - Nishizaki, K
AU  - Nishizaki K
FAU - Nomiya, S
AU  - Nomiya S
FAU - Masuda, Y
AU  - Masuda Y
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Acta Otolaryngol Suppl
JT  - Acta oto-laryngologica. Supplementum
JID - 0370355
RN  - 0 (Calbindins)
RN  - 0 (Calmodulin)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (S100 Calcium Binding Protein G)
SB  - IM
MH  - Animals
MH  - Calbindins
MH  - Calmodulin/*metabolism
MH  - Female
MH  - Hair Cells, Auditory/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Nerve Tissue Proteins/*metabolism
MH  - S100 Calcium Binding Protein G/*metabolism
MH  - Shrews/*growth & development
MH  - Vestibule, Labyrinth/chemistry/*growth & development
EDAT- 1999/08/13 00:00
MHDA- 1999/08/13 00:01
CRDT- 1999/08/13 00:00
PHST- 1999/08/13 00:00 [pubmed]
PHST- 1999/08/13 00:01 [medline]
PHST- 1999/08/13 00:00 [entrez]
PST - ppublish
SO  - Acta Otolaryngol Suppl. 1999;540:16-21.