PMID- 10446793
OWN - NLM
STAT- MEDLINE
DCOM- 19990928
LR  - 20161018
IS  - 0892-7790 (Print)
IS  - 0892-7790 (Linking)
VI  - 13
IP  - 5
DP  - 1999 Jun
TI  - Limitation of shockwave-induced enhanced crystal deposition in traumatized tissue 
      by verapamil in rabbit model.
PG  - 343-7
AB  - OBJECTIVE: To evaluate the possible protective effect of verapamil (a calcium 
      channel blocking agent) against the traumatizing effects of high-energy 
      shockwaves (HESW) and new stone formation, as indicated by crystal deposition in 
      the renal parenchyma, an experimental study was performed in rabbits. METHODS: A 
      total of 65 rabbits were included. During severe hyperoxaluria induced by 
      continuous ethylene glycol (EG) (0.75%) administration, animals in the first 
      group (N = 15) received EG only, and animals in the second group underwent 
      administration of 500 to 1500 shockwaves, animals in the third group (N = 15) 
      received verapamil (0.1 mg/kg) for 3 days prior to HESW application, a control 
      group (N = 15) received various numbers (500 to 1500) of shockwaves alone. 
      Sham-treated animals (N = 5) constituted the last group in our study. Three 
      months after shockwave application, tissue sections obtained from treated and 
      untreated kidneys were evaluated histopathologically under light microscopy and 
      transmission electron microscopy (TEM) for the presence and degree of crystal 
      deposition in the cortical parenchymal region subjected to HESW. RESULTS: Whereas 
      crystal deposition was evident in the intercellular region and intratubular parts 
      of the parenchyma in animals receiving EG and HESW, especially in those receiving 
      relatively higher numbers of shockwaves), animals receiving verapamil 
      demonstrated limited or no crystal formation. No significant crystal deposition 
      could be noted in specimens from animals undergoing either EG or SWL alone, and 
      sham-treated animals demonstrated no significant alteration, as expected. 
      CONCLUSION: Using this model, the traumatic effects of HESW could be evaluated as 
      a factor in new stone formation after SWL. Verapamil has been found to be 
      protective against crystal deposition.
FAU - Sarica, K
AU  - Sarica K
AD  - Department of Urology, Sahinbey Hospital, University of Gaziantep Medical School, 
      Turkey. kemalsarica@superonline.com
FAU - Bakir, K
AU  - Bakir K
FAU - Yagci, F
AU  - Yagci F
FAU - Topcu, O
AU  - Topcu O
FAU - Akbay, C
AU  - Akbay C
FAU - Sayin, N
AU  - Sayin N
FAU - Korkmaz, C
AU  - Korkmaz C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 0 (Calcium Channel Blockers)
RN  - CJ0O37KU29 (Verapamil)
SB  - IM
MH  - Animals
MH  - Calcium Channel Blockers/*therapeutic use
MH  - Disease Models, Animal
MH  - Kidney/*drug effects/injuries/pathology
MH  - Kidney Calculi/etiology/pathology/*prevention & control
MH  - Lithotripsy/*adverse effects
MH  - Prospective Studies
MH  - Rabbits
MH  - Secondary Prevention
MH  - Verapamil/*therapeutic use
EDAT- 1999/08/14 00:00
MHDA- 1999/08/14 00:01
CRDT- 1999/08/14 00:00
PHST- 1999/08/14 00:00 [pubmed]
PHST- 1999/08/14 00:01 [medline]
PHST- 1999/08/14 00:00 [entrez]
AID - 10.1089/end.1999.13.343 [doi]
PST - ppublish
SO  - J Endourol. 1999 Jun;13(5):343-7. doi: 10.1089/end.1999.13.343.