PMID- 10447752
OWN - NLM
STAT- MEDLINE
DCOM- 20000404
LR  - 20190513
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 97
IP  - 2
DP  - 1999 Jun
TI  - The incidence of japanese cedar pollinosis and sensitization to the pollen 
      allergens among Japanese monkeys in a troop.
PG  - 348-51
AB  - The natural occurrence of Japanese cedar (Cryptomeria japonica; CJ) pollinosis 
      has been reported in Japanese monkeys (Macaca fuscata), an appropriate animal 
      model for developing antipollinosis therapies. However, there has been no study 
      on the incidence of Japanese cedar pollinosis in monkeys. To evaluate the 
      incidence of CJ pollinosis in Japanese monkeys, we investigated the presence of 
      pollinosis symptoms among monkeys in a troop, and the response to CJ allergens in 
      pollinosis monkeys. We examined the presence of pollinosis symptoms in 272 
      monkeys in a troop throughout the CJ pollination season (February to April). Of 
      the 272 monkeys, 21 (7.7%) showed pollinosis symptoms during the CJ pollen 
      season. Blood samples were taken from the 21 monkeys that showed pollinosis 
      symptoms and were tested for the presence of immunoglobulin E (IgE) antibody for 
      CJ allergens. All 21 monkeys with CJ pollinosis had anti-CJ IgE. Of the 21 
      monkeys, peripheral blood mononuclear cells (PBMC) could be taken from 12, all of 
      which showed CJ allergen-specific PBMC proliferation. The incidence of CJ 
      pollinosis in a troop was 7.7%. The monkeys with CJ pollinosis demonstrated 
      specific IgE and PBMC proliferation for CJ allergens.
FAU - Sakaguchi, M
AU  - Sakaguchi M
AD  - Department of Immunology, National Institute of Infectious Diseases, Toyama, 
      Tokyo, Japan.
FAU - Kobayashi, C
AU  - Kobayashi C
FAU - Inouye, S
AU  - Inouye S
FAU - Saito, S
AU  - Saito S
FAU - Hirahara, K
AU  - Hirahara K
FAU - Shiraishi, A
AU  - Shiraishi A
FAU - Konaka, A
AU  - Konaka A
FAU - Yamada, T
AU  - Yamada T
FAU - Nigi, H
AU  - Nigi H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Cry j I protein, Cryptomeria japonica)
RN  - 0 (Cry j II protein, Cryptomeria japonica)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Plant
MH  - Cell Division/immunology
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Incidence
MH  - Japan/epidemiology
MH  - Leukocytes, Mononuclear/immunology
MH  - Macaca/*immunology
MH  - Male
MH  - Monkey Diseases/*epidemiology/immunology
MH  - Plant Proteins/immunology
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/*epidemiology/*veterinary
PMC - PMC2326834
EDAT- 1999/08/14 10:00
MHDA- 2001/07/04 10:01
PMCR- 2000/06/01
CRDT- 1999/08/14 10:00
PHST- 1999/08/14 10:00 [pubmed]
PHST- 2001/07/04 10:01 [medline]
PHST- 1999/08/14 10:00 [entrez]
PHST- 2000/06/01 00:00 [pmc-release]
AID - imm792 [pii]
AID - 10.1046/j.1365-2567.1999.00792.x [doi]
PST - ppublish
SO  - Immunology. 1999 Jun;97(2):348-51. doi: 10.1046/j.1365-2567.1999.00792.x.