PMID- 10448661
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20051117
IS  - 0344-0338 (Print)
IS  - 0344-0338 (Linking)
VI  - 195
IP  - 7
DP  - 1999
TI  - A progression to dermatofibrosarcoma protuberans with a fibrosarcomatous 
      component: a special reference to the chromosomal aberrations.
PG  - 451-60
AB  - Dermatofibrosarcoma protuberans (DFSP) with fibrosarcomatous areas (DFSP-FS) is 
      differentiated from ordinary DFSP by its unfavourable prognosis. We carried out 
      sequential analysis of numerical chromosomal abnormalities in two cases of DFSP 
      during their progression to metastatic disease with FS areas (DFSP-M-FS). They 
      were compared with nine cases of ordinary DFSP and three cases of DFSP-FS, but 
      without metastases. Numerical chromosomal changes were examined by fluorescence 
      in situ hybridization (FISH) using alpha-satellite centromeric probes for 
      chromosomes 1, 8, 11 and 17. Numerical imbalances of chromosome 1 were not 
      clarified. A gain of chromosome 8 was demonstrated in the two cases of DFSP-M-FS. 
      A gain of chromosome 11 was observed in one of the two cases of DFSP-M-FS and in 
      one case of DFSP-FS. A gain of chromosome 17 was demonstrated in both metastatic 
      tumours and in recurrent tumours in two cases of DFSP-M-FS, in addition to two 
      cases of DFSP-FS and four cases of ordinary DFSP with recurrent tumours or large 
      tumours. This study raised the hypothesis that a gain of chromosome 17 developed 
      in recurrent or large-sized DFSP, which occurs in high-risk groups with the 
      possibility of a progression to FS.
FAU - Hamada, M
AU  - Hamada M
AD  - Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Hirakawa, N
AU  - Hirakawa N
FAU - Fukuda, T
AU  - Fukuda T
FAU - Furue, M
AU  - Furue M
FAU - Hori, Y
AU  - Hori Y
FAU - Tsuneyoshi, M
AU  - Tsuneyoshi M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - Chromosome Aberrations/*genetics
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Dermatofibrosarcoma/*diagnosis/genetics/metabolism/pathology
MH  - Disease Progression
MH  - Female
MH  - Fibrosarcoma/*diagnosis/genetics/metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mitotic Index
MH  - Prognosis
MH  - Skin Neoplasms/*diagnosis/genetics/metabolism/pathology
MH  - Tumor Suppressor Protein p53/metabolism
EDAT- 1999/08/17 00:00
MHDA- 1999/08/17 00:01
CRDT- 1999/08/17 00:00
PHST- 1999/08/17 00:00 [pubmed]
PHST- 1999/08/17 00:01 [medline]
PHST- 1999/08/17 00:00 [entrez]
AID - S0344-0338(99)80048-X [pii]
AID - 10.1016/S0344-0338(99)80048-X [doi]
PST - ppublish
SO  - Pathol Res Pract. 1999;195(7):451-60. doi: 10.1016/S0344-0338(99)80048-X.