PMID- 10451708
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20071115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 24
IP  - 3
DP  - 1999 Mar
TI  - Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic 
      leukemia with TEL/AML1 gene fusion.
PG  - 272-7
AB  - TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute 
      lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic 
      chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive 
      TEL/AML1 patients, karyotype examination by GTG banding and fluorescence in situ 
      hybridization (FISH) allowed us to identify chromosome anomalies in addition to 
      the already existing t(12;21). Secondary aberrations were found in 29 out of 41 
      patients (71%) at initial diagnosis and in all 9 patients with relapse. 
      Structural rearrangements affected chromosome arms 2p, 2q, 5q, 9p, 12p (n = 2), 
      6q, 11p (n = 3), and 21q (n = 4). An extra chromosome 21 was found to be the most 
      frequent anomaly. It was detected in 6 out of 41 patients at initial diagnosis 
      (15%) and in 7 out of the 9 patients at relapse. No karyotype with trisomy 21 
      exceeded 47 chromosomes. Gain of chromosome 21 was the sole anomaly in 
      GTG-banding analysis in 2/41 patients at initial diagnosis and in 4/9 at relapse. 
      Notably, chromosome painting analysis performed in 11 out of the 13 patients with 
      an extra chromosome 21 revealed duplication of the normal chromosome 21 in 8, and 
      duplication of der(21)t(12;21) in 3 patients. Furthermore, gain of 
      der(21)t(12;21) chromosome was confined exclusively to the relapse patients.
FAU - Loncarevic, I F
AU  - Loncarevic IF
AD  - Children's University Hospital, Giessen, Germany.
FAU - Roitzheim, B
AU  - Roitzheim B
FAU - Ritterbach, J
AU  - Ritterbach J
FAU - Viehmann, S
AU  - Viehmann S
FAU - Borkhardt, A
AU  - Borkhardt A
FAU - Lampert, F
AU  - Lampert F
FAU - Harbott, J
AU  - Harbott J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Child
MH  - Chromosome Aberrations/*genetics
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Down Syndrome/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Neoplasm Proteins/*genetics
MH  - *Oncogene Proteins, Fusion
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Recurrence
MH  - Translocation, Genetic/*genetics
EDAT- 1999/08/19 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/08/19 10:00
PHST- 1999/08/19 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/08/19 10:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199903)24:3<272::AID-GCC13>3.0.CO;2-U [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Mar;24(3):272-7.