PMID- 10453051
OWN - NLM
STAT- MEDLINE
DCOM- 19991004
LR  - 20191103
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 40
IP  - 4
DP  - 1999 Sep 15
TI  - Estrogen and microglia: A regulatory system that affects the brain.
PG  - 484-96
AB  - Sex hormones are involved in the physiological regulation of several aspects of 
      behavior and neuroendocrine events. It has been accepted that such effects are 
      mediated directly by steroid actions on neurons; however, new studies have shown 
      that the glial cells are also affected by gonadal steroids. The microglia are one 
      specialized brain glial cell type, which is a target for estrogen actions. In 
      fact, we believe that many of the immune and nonimmune regulatory functions of 
      microglia in the brain are influenced directly by estrogen via expression and 
      secretion of cytokines, and growth factors by the microglia. The present review 
      details only a section of the known aspects of microglial function, focusing 
      mainly on nonimmune regulatory actions in the brain and their functional 
      relationship with sex hormones. Moreover, we present evidence for the presence of 
      estrogen receptor-beta (ERbeta) in rat microglial cells.
CI  - Copyright 1999 John Wiley & Sons, Inc.
FAU - Mor, G
AU  - Mor G
AD  - Department of Obstetrics and Gynecology and Center for Reproductive Biology, Yale 
      University Medical School, 333 Cedar St. FMB 202, New Haven, Connecticut 06520, 
      USA.
FAU - Nilsen, J
AU  - Nilsen J
FAU - Horvath, T
AU  - Horvath T
FAU - Bechmann, I
AU  - Bechmann I
FAU - Brown, S
AU  - Brown S
FAU - Garcia-Segura, L M
AU  - Garcia-Segura LM
FAU - Naftolin, F
AU  - Naftolin F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - Brain/immunology/*physiology
MH  - Estrogens/immunology/metabolism/*physiology
MH  - Humans
MH  - Microglia/immunology/metabolism/*physiology
MH  - Receptors, Estrogen/metabolism/physiology
RF  - 130
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - 10.1002/(SICI)1097-4695(19990915)40:4<484::AID-NEU6>3.0.CO;2-C [pii]
AID - 10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c [doi]
PST - ppublish
SO  - J Neurobiol. 1999 Sep 15;40(4):484-96. doi: 
      10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c.