PMID- 10453911
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20191024
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 13
IP  - 4
DP  - 1999 Jul-Aug
TI  - Cadmium affects testes and semen of rabbits exposed before and after puberty.
PG  - 269-77
AB  - Semen quality and testicular characteristics were measured in 92 rabbits in three 
      controlled experiments with males exposed to cadmium chloride (Cd) when 12 or 27 
      weeks old. Doses of Cd were administered subcutaneously (s.c.), orally, or 
      intravenously (i.v.) and subsets of animals were unilaterally castrated or not to 
      evaluate the testes and to collect semen repeatedly from males when adults. There 
      was considerable variability but Cd given at 12 weeks of age in doses of 0.08 
      mmol/kg s.c., 0.20 mmol/kg orally, and 0.02 mmol/kg i.v. tended to depress sperm 
      output of these males when adults. The 0.02 mmol/kg dose given i.v., 0.4 mmol/kg 
      orally, and 0.16 mmol/kg s.c. were lethal to many animals. Treatment of adults 
      resulted in a generally similar pattern of systemic toxicity, and limited 
      comparisons suggested that testicular sensitivity was slightly less than for 
      young males. Androgenic function usually was maintained, as indicated by normal 
      libido and seminal volumes even in males with reduced spermatogenesis. Necropsies 
      confirmed previous findings of hyperemia, hemorrhaging, necrosis, and destruction 
      of all spermatogenic elements in severely affected males.
FAU - Foote, R H
AU  - Foote RH
AD  - Department of Animal Science, Cornell University, Ithaca, New York 14853-4801, 
      USA. dgb1@Cornell.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 00BH33GNGH (Cadmium)
RN  - J6K4F9V3BA (Cadmium Chloride)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cadmium/*toxicity
MH  - Cadmium Chloride/administration & dosage
MH  - Injections, Intravenous
MH  - Injections, Subcutaneous
MH  - Male
MH  - Rabbits
MH  - Semen/*drug effects
MH  - Sexual Maturation/*physiology
MH  - Sperm Motility/drug effects
MH  - Spermatogenesis/drug effects
MH  - Spermatozoa/drug effects
MH  - Testis/*drug effects/physiology
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - S0890623899000192 [pii]
AID - 10.1016/s0890-6238(99)00019-2 [doi]
PST - ppublish
SO  - Reprod Toxicol. 1999 Jul-Aug;13(4):269-77. doi: 10.1016/s0890-6238(99)00019-2.